The Antiviral Activities of Poly-ADP-Ribose Polymerases

The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of translation and cell death. In addition to these phy...

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Detalles Bibliográficos
Autores principales: Malgras, Mathilde, Garcia, Magali, Jousselin, Clément, Bodet, Charles, Lévêque, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066025/
https://www.ncbi.nlm.nih.gov/pubmed/33808354
http://dx.doi.org/10.3390/v13040582
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author Malgras, Mathilde
Garcia, Magali
Jousselin, Clément
Bodet, Charles
Lévêque, Nicolas
author_facet Malgras, Mathilde
Garcia, Magali
Jousselin, Clément
Bodet, Charles
Lévêque, Nicolas
author_sort Malgras, Mathilde
collection PubMed
description The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of translation and cell death. In addition to these physiological functions, recent studies have highlighted the role of PARPs in host defenses against viruses, either by direct antiviral activity, targeting certain steps of virus replication cycle, or indirect antiviral activity, via modulation of the innate immune response. This review focuses on the antiviral activity of PARPs, as well as strategies developed by viruses to escape their action.
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spelling pubmed-80660252021-04-25 The Antiviral Activities of Poly-ADP-Ribose Polymerases Malgras, Mathilde Garcia, Magali Jousselin, Clément Bodet, Charles Lévêque, Nicolas Viruses Review The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of translation and cell death. In addition to these physiological functions, recent studies have highlighted the role of PARPs in host defenses against viruses, either by direct antiviral activity, targeting certain steps of virus replication cycle, or indirect antiviral activity, via modulation of the innate immune response. This review focuses on the antiviral activity of PARPs, as well as strategies developed by viruses to escape their action. MDPI 2021-03-30 /pmc/articles/PMC8066025/ /pubmed/33808354 http://dx.doi.org/10.3390/v13040582 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malgras, Mathilde
Garcia, Magali
Jousselin, Clément
Bodet, Charles
Lévêque, Nicolas
The Antiviral Activities of Poly-ADP-Ribose Polymerases
title The Antiviral Activities of Poly-ADP-Ribose Polymerases
title_full The Antiviral Activities of Poly-ADP-Ribose Polymerases
title_fullStr The Antiviral Activities of Poly-ADP-Ribose Polymerases
title_full_unstemmed The Antiviral Activities of Poly-ADP-Ribose Polymerases
title_short The Antiviral Activities of Poly-ADP-Ribose Polymerases
title_sort antiviral activities of poly-adp-ribose polymerases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066025/
https://www.ncbi.nlm.nih.gov/pubmed/33808354
http://dx.doi.org/10.3390/v13040582
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