Cargando…

Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital

Clinical trials in cancer treatment are imperative in enhancing patients’ survival and quality of life outcomes. The lack of communication among professionals may produce a non-optimization of patients’ accrual in clinical trials. We developed a specific platform, called “Digital Research Assistant”...

Descripción completa

Detalles Bibliográficos
Autores principales: Cesario, Alfredo, Simone, Irene, Paris, Ida, Boldrini, Luca, Orlandi, Armando, Franceschini, Gianluca, Lococo, Filippo, Bria, Emilio, Magno, Stefano, Mulè, Antonino, Santoro, Angela, Damiani, Andrea, Bianchi, Daniele, Picchi, Daniele, Rasi, Guido, Daniele, Gennaro, Fabi, Alessandra, Sergi, Paolo, Tortora, Giampaolo, Masetti, Riccardo, Valentini, Vincenzo, D’Oria, Marika, Scambia, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066078/
https://www.ncbi.nlm.nih.gov/pubmed/33801668
http://dx.doi.org/10.3390/jpm11040244
_version_ 1783682490569850880
author Cesario, Alfredo
Simone, Irene
Paris, Ida
Boldrini, Luca
Orlandi, Armando
Franceschini, Gianluca
Lococo, Filippo
Bria, Emilio
Magno, Stefano
Mulè, Antonino
Santoro, Angela
Damiani, Andrea
Bianchi, Daniele
Picchi, Daniele
Rasi, Guido
Daniele, Gennaro
Fabi, Alessandra
Sergi, Paolo
Tortora, Giampaolo
Masetti, Riccardo
Valentini, Vincenzo
D’Oria, Marika
Scambia, Giovanni
author_facet Cesario, Alfredo
Simone, Irene
Paris, Ida
Boldrini, Luca
Orlandi, Armando
Franceschini, Gianluca
Lococo, Filippo
Bria, Emilio
Magno, Stefano
Mulè, Antonino
Santoro, Angela
Damiani, Andrea
Bianchi, Daniele
Picchi, Daniele
Rasi, Guido
Daniele, Gennaro
Fabi, Alessandra
Sergi, Paolo
Tortora, Giampaolo
Masetti, Riccardo
Valentini, Vincenzo
D’Oria, Marika
Scambia, Giovanni
author_sort Cesario, Alfredo
collection PubMed
description Clinical trials in cancer treatment are imperative in enhancing patients’ survival and quality of life outcomes. The lack of communication among professionals may produce a non-optimization of patients’ accrual in clinical trials. We developed a specific platform, called “Digital Research Assistant” (DRA), to report real-time every available clinical trial and support clinician. Healthcare professionals involved in breast cancer working group agreed nine minimal fields of interest to preliminarily classify the characteristics of patients’ records (including omic data, such as genomic mutations). A progressive web app (PWA) was developed to implement a cross-platform software that was scalable on several electronic devices to share the patients’ records and clinical trials. A specialist is able to use and populate the platform. An AI algorithm helps in the matchmaking between patient’s data and clinical trial’s inclusion criteria to personalize patient enrollment. At the same time, an easy configuration allows the application of the DRA in different oncology working groups (from breast cancer to lung cancer). The DRA might represent a valid research tool supporting clinicians and scientists, in order to optimize the enrollment of patients in clinical trials. User Experience and Technology The acceptance of participants using the DRA is topic of a future analysis.
format Online
Article
Text
id pubmed-8066078
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80660782021-04-25 Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital Cesario, Alfredo Simone, Irene Paris, Ida Boldrini, Luca Orlandi, Armando Franceschini, Gianluca Lococo, Filippo Bria, Emilio Magno, Stefano Mulè, Antonino Santoro, Angela Damiani, Andrea Bianchi, Daniele Picchi, Daniele Rasi, Guido Daniele, Gennaro Fabi, Alessandra Sergi, Paolo Tortora, Giampaolo Masetti, Riccardo Valentini, Vincenzo D’Oria, Marika Scambia, Giovanni J Pers Med Article Clinical trials in cancer treatment are imperative in enhancing patients’ survival and quality of life outcomes. The lack of communication among professionals may produce a non-optimization of patients’ accrual in clinical trials. We developed a specific platform, called “Digital Research Assistant” (DRA), to report real-time every available clinical trial and support clinician. Healthcare professionals involved in breast cancer working group agreed nine minimal fields of interest to preliminarily classify the characteristics of patients’ records (including omic data, such as genomic mutations). A progressive web app (PWA) was developed to implement a cross-platform software that was scalable on several electronic devices to share the patients’ records and clinical trials. A specialist is able to use and populate the platform. An AI algorithm helps in the matchmaking between patient’s data and clinical trial’s inclusion criteria to personalize patient enrollment. At the same time, an easy configuration allows the application of the DRA in different oncology working groups (from breast cancer to lung cancer). The DRA might represent a valid research tool supporting clinicians and scientists, in order to optimize the enrollment of patients in clinical trials. User Experience and Technology The acceptance of participants using the DRA is topic of a future analysis. MDPI 2021-03-27 /pmc/articles/PMC8066078/ /pubmed/33801668 http://dx.doi.org/10.3390/jpm11040244 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Cesario, Alfredo
Simone, Irene
Paris, Ida
Boldrini, Luca
Orlandi, Armando
Franceschini, Gianluca
Lococo, Filippo
Bria, Emilio
Magno, Stefano
Mulè, Antonino
Santoro, Angela
Damiani, Andrea
Bianchi, Daniele
Picchi, Daniele
Rasi, Guido
Daniele, Gennaro
Fabi, Alessandra
Sergi, Paolo
Tortora, Giampaolo
Masetti, Riccardo
Valentini, Vincenzo
D’Oria, Marika
Scambia, Giovanni
Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital
title Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital
title_full Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital
title_fullStr Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital
title_full_unstemmed Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital
title_short Development of a Digital Research Assistant for the Management of Patients’ Enrollment in Oncology Clinical Trials within a Research Hospital
title_sort development of a digital research assistant for the management of patients’ enrollment in oncology clinical trials within a research hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066078/
https://www.ncbi.nlm.nih.gov/pubmed/33801668
http://dx.doi.org/10.3390/jpm11040244
work_keys_str_mv AT cesarioalfredo developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT simoneirene developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT parisida developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT boldriniluca developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT orlandiarmando developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT franceschinigianluca developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT lococofilippo developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT briaemilio developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT magnostefano developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT muleantonino developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT santoroangela developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT damianiandrea developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT bianchidaniele developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT picchidaniele developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT rasiguido developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT danielegennaro developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT fabialessandra developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT sergipaolo developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT tortoragiampaolo developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT masettiriccardo developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT valentinivincenzo developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT doriamarika developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital
AT scambiagiovanni developmentofadigitalresearchassistantforthemanagementofpatientsenrollmentinoncologyclinicaltrialswithinaresearchhospital