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Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis

Inflammation-modulating elements are recognized periodontitis (PD) risk factors, nevertheless, the association between dietary inflammatory index (DII) and PD has never been appraised. We aimed to assess the association between DII and PD and the mediation effect of DII in the association of PD with...

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Autores principales: Machado, Vanessa, Botelho, João, Viana, João, Pereira, Paula, Lopes, Luísa Bandeira, Proença, Luís, Delgado, Ana Sintra, Mendes, José João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066166/
https://www.ncbi.nlm.nih.gov/pubmed/33916342
http://dx.doi.org/10.3390/nu13041194
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author Machado, Vanessa
Botelho, João
Viana, João
Pereira, Paula
Lopes, Luísa Bandeira
Proença, Luís
Delgado, Ana Sintra
Mendes, José João
author_facet Machado, Vanessa
Botelho, João
Viana, João
Pereira, Paula
Lopes, Luísa Bandeira
Proença, Luís
Delgado, Ana Sintra
Mendes, José João
author_sort Machado, Vanessa
collection PubMed
description Inflammation-modulating elements are recognized periodontitis (PD) risk factors, nevertheless, the association between dietary inflammatory index (DII) and PD has never been appraised. We aimed to assess the association between DII and PD and the mediation effect of DII in the association of PD with systemic inflammation. Using the National Health and Nutrition Examination Survey 2009–2010, 2011–2012 and 2013–2014, participants who received periodontal exam and provided dietary recall data were included. The inflammatory potential of diet was calculated via DII. PD was defined according to the 2012 case definition. White blood cells (WBC), segmented neutrophils and C-reactive protein (CRP) were used as proxies for systemic inflammation. The periodontal measures were regressed across DII values using adjusted multivariate linear regression and adjusted mediation analysis. Overall, 10,178 participants were included. DII was significantly correlated with mean periodontal probing depth (PPD), mean clinical attachment loss (CAL), thresholds of PPD and CAL, WBC, segmented neutrophils and DII (p < 0.01). A linear regression logistic adjusted for multiple confounding variables confirmed the association between DII and mean PPD (B = 0.02, Standard Error [SE]: 0.02, p < 0.001) and CAL (B = −0.02, SE: 0.01, p < 0.001). The association of mean PPD and mean CAL with both WBC and segmented neutrophils were mediated by DII (from 2.1 to 3.5%, p < 0.001). In the 2009–2010 subset, the association of mean CAL with serum CRP was mediated by DII (52.0%, p < 0.01). Inflammatory diet and PD may be associated. Also, the inflammatory diet significantly mediated the association of leukocyte counts and systemic inflammation with PD.
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spelling pubmed-80661662021-04-25 Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis Machado, Vanessa Botelho, João Viana, João Pereira, Paula Lopes, Luísa Bandeira Proença, Luís Delgado, Ana Sintra Mendes, José João Nutrients Article Inflammation-modulating elements are recognized periodontitis (PD) risk factors, nevertheless, the association between dietary inflammatory index (DII) and PD has never been appraised. We aimed to assess the association between DII and PD and the mediation effect of DII in the association of PD with systemic inflammation. Using the National Health and Nutrition Examination Survey 2009–2010, 2011–2012 and 2013–2014, participants who received periodontal exam and provided dietary recall data were included. The inflammatory potential of diet was calculated via DII. PD was defined according to the 2012 case definition. White blood cells (WBC), segmented neutrophils and C-reactive protein (CRP) were used as proxies for systemic inflammation. The periodontal measures were regressed across DII values using adjusted multivariate linear regression and adjusted mediation analysis. Overall, 10,178 participants were included. DII was significantly correlated with mean periodontal probing depth (PPD), mean clinical attachment loss (CAL), thresholds of PPD and CAL, WBC, segmented neutrophils and DII (p < 0.01). A linear regression logistic adjusted for multiple confounding variables confirmed the association between DII and mean PPD (B = 0.02, Standard Error [SE]: 0.02, p < 0.001) and CAL (B = −0.02, SE: 0.01, p < 0.001). The association of mean PPD and mean CAL with both WBC and segmented neutrophils were mediated by DII (from 2.1 to 3.5%, p < 0.001). In the 2009–2010 subset, the association of mean CAL with serum CRP was mediated by DII (52.0%, p < 0.01). Inflammatory diet and PD may be associated. Also, the inflammatory diet significantly mediated the association of leukocyte counts and systemic inflammation with PD. MDPI 2021-04-05 /pmc/articles/PMC8066166/ /pubmed/33916342 http://dx.doi.org/10.3390/nu13041194 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Machado, Vanessa
Botelho, João
Viana, João
Pereira, Paula
Lopes, Luísa Bandeira
Proença, Luís
Delgado, Ana Sintra
Mendes, José João
Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis
title Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis
title_full Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis
title_fullStr Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis
title_full_unstemmed Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis
title_short Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis
title_sort association between dietary inflammatory index and periodontitis: a cross-sectional and mediation analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066166/
https://www.ncbi.nlm.nih.gov/pubmed/33916342
http://dx.doi.org/10.3390/nu13041194
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