BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19

BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2,...

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Autores principales: Ji, Rui-Ru, Qu, Yajin, Zhu, Hua, Yang, Yumei, Vogel, Annette B., Sahin, Ugur, Qin, Chuan, Hui, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066210/
https://www.ncbi.nlm.nih.gov/pubmed/33915773
http://dx.doi.org/10.3390/vaccines9040324
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author Ji, Rui-Ru
Qu, Yajin
Zhu, Hua
Yang, Yumei
Vogel, Annette B.
Sahin, Ugur
Qin, Chuan
Hui, Aimin
author_facet Ji, Rui-Ru
Qu, Yajin
Zhu, Hua
Yang, Yumei
Vogel, Annette B.
Sahin, Ugur
Qin, Chuan
Hui, Aimin
author_sort Ji, Rui-Ru
collection PubMed
description BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
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spelling pubmed-80662102021-04-25 BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19 Ji, Rui-Ru Qu, Yajin Zhu, Hua Yang, Yumei Vogel, Annette B. Sahin, Ugur Qin, Chuan Hui, Aimin Vaccines (Basel) Brief Report BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge. MDPI 2021-04-01 /pmc/articles/PMC8066210/ /pubmed/33915773 http://dx.doi.org/10.3390/vaccines9040324 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Ji, Rui-Ru
Qu, Yajin
Zhu, Hua
Yang, Yumei
Vogel, Annette B.
Sahin, Ugur
Qin, Chuan
Hui, Aimin
BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_full BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_fullStr BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_full_unstemmed BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_short BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_sort bnt162b2 vaccine encoding the sars-cov-2 p2 s protects transgenic hace2 mice against covid-19
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066210/
https://www.ncbi.nlm.nih.gov/pubmed/33915773
http://dx.doi.org/10.3390/vaccines9040324
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