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Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project
Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066231/ https://www.ncbi.nlm.nih.gov/pubmed/33801760 http://dx.doi.org/10.3390/microorganisms9040696 |
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author | Bennett, Julia C. Hetrich, Marissa K. Garcia Quesada, Maria Sinkevitch, Jenna N. Deloria Knoll, Maria Feikin, Daniel R. Zeger, Scott L. Kagucia, Eunice W. Cohen, Adam L. Ampofo, Krow Brandileone, Maria-Cristina C. Bruden, Dana Camilli, Romina Castilla, Jesús Chan, Guanhao Cook, Heather Cornick, Jennifer E. Dagan, Ron Dalby, Tine Danis, Kostas de Miguel, Sara De Wals, Philippe Desmet, Stefanie Georgakopoulou, Theano Gilkison, Charlotte Grgic-Vitek, Marta Hammitt, Laura L. Hilty, Markus Ho, Pak-Leung Jayasinghe, Sanjay Kellner, James D. Kleynhans, Jackie Knol, Mirjam J. Kozakova, Jana Kristinsson, Karl G. Ladhani, Shamez N. MacDonald, Laura Mackenzie, Grant A. Mad’arová, Lucia McGeer, Allison Mereckiene, Jolita Morfeldt, Eva Mungun, Tuya Muñoz-Almagro, Carmen Nuorti, J. Pekka Paragi, Metka Pilishvili, Tamara Puentes, Rodrigo Saha, Samir K. Sahu Khan, Aalisha Savrasova, Larisa Scott, J. Anthony Skoczyńska, Anna Suga, Shigeru van der Linden, Mark Verani, Jennifer R. von Gottberg, Anne Winje, Brita A. Yildirim, Inci Zerouali, Khalid Hayford, Kyla |
author_facet | Bennett, Julia C. Hetrich, Marissa K. Garcia Quesada, Maria Sinkevitch, Jenna N. Deloria Knoll, Maria Feikin, Daniel R. Zeger, Scott L. Kagucia, Eunice W. Cohen, Adam L. Ampofo, Krow Brandileone, Maria-Cristina C. Bruden, Dana Camilli, Romina Castilla, Jesús Chan, Guanhao Cook, Heather Cornick, Jennifer E. Dagan, Ron Dalby, Tine Danis, Kostas de Miguel, Sara De Wals, Philippe Desmet, Stefanie Georgakopoulou, Theano Gilkison, Charlotte Grgic-Vitek, Marta Hammitt, Laura L. Hilty, Markus Ho, Pak-Leung Jayasinghe, Sanjay Kellner, James D. Kleynhans, Jackie Knol, Mirjam J. Kozakova, Jana Kristinsson, Karl G. Ladhani, Shamez N. MacDonald, Laura Mackenzie, Grant A. Mad’arová, Lucia McGeer, Allison Mereckiene, Jolita Morfeldt, Eva Mungun, Tuya Muñoz-Almagro, Carmen Nuorti, J. Pekka Paragi, Metka Pilishvili, Tamara Puentes, Rodrigo Saha, Samir K. Sahu Khan, Aalisha Savrasova, Larisa Scott, J. Anthony Skoczyńska, Anna Suga, Shigeru van der Linden, Mark Verani, Jennifer R. von Gottberg, Anne Winje, Brita A. Yildirim, Inci Zerouali, Khalid Hayford, Kyla |
author_sort | Bennett, Julia C. |
collection | PubMed |
description | Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to each post-PCV10/13 year by site using a Bayesian multi-level, mixed-effects Poisson regression and all-site IRRs using a linear mixed-effects regression (N = 45 sites). Following PCV10/13 introduction, the incidence rate (IR) of ST1 IPD declined among all ages. After six years of PCV10/13 use, the all-site IRR was 0.05 (95% credibility interval 0.04–0.06) for all ages, 0.05 (0.04–0.05) for <5 years of age, 0.08 (0.06–0.09) for 5–17 years, 0.06 (0.05–0.08) for 18–49 years, 0.06 (0.05–0.07) for 50–64 years, and 0.05 (0.04–0.06) for ≥65 years. PCV10/13 use in infant immunization programs was followed by a 95% reduction in ST1 IPD in all ages after approximately 6 years. Limited data availability from the highest ST1 disease burden countries using a 3 + 0 schedule constrains generalizability and data from these settings are needed. |
format | Online Article Text |
id | pubmed-8066231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80662312021-04-25 Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project Bennett, Julia C. Hetrich, Marissa K. Garcia Quesada, Maria Sinkevitch, Jenna N. Deloria Knoll, Maria Feikin, Daniel R. Zeger, Scott L. Kagucia, Eunice W. Cohen, Adam L. Ampofo, Krow Brandileone, Maria-Cristina C. Bruden, Dana Camilli, Romina Castilla, Jesús Chan, Guanhao Cook, Heather Cornick, Jennifer E. Dagan, Ron Dalby, Tine Danis, Kostas de Miguel, Sara De Wals, Philippe Desmet, Stefanie Georgakopoulou, Theano Gilkison, Charlotte Grgic-Vitek, Marta Hammitt, Laura L. Hilty, Markus Ho, Pak-Leung Jayasinghe, Sanjay Kellner, James D. Kleynhans, Jackie Knol, Mirjam J. Kozakova, Jana Kristinsson, Karl G. Ladhani, Shamez N. MacDonald, Laura Mackenzie, Grant A. Mad’arová, Lucia McGeer, Allison Mereckiene, Jolita Morfeldt, Eva Mungun, Tuya Muñoz-Almagro, Carmen Nuorti, J. Pekka Paragi, Metka Pilishvili, Tamara Puentes, Rodrigo Saha, Samir K. Sahu Khan, Aalisha Savrasova, Larisa Scott, J. Anthony Skoczyńska, Anna Suga, Shigeru van der Linden, Mark Verani, Jennifer R. von Gottberg, Anne Winje, Brita A. Yildirim, Inci Zerouali, Khalid Hayford, Kyla Microorganisms Article Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to each post-PCV10/13 year by site using a Bayesian multi-level, mixed-effects Poisson regression and all-site IRRs using a linear mixed-effects regression (N = 45 sites). Following PCV10/13 introduction, the incidence rate (IR) of ST1 IPD declined among all ages. After six years of PCV10/13 use, the all-site IRR was 0.05 (95% credibility interval 0.04–0.06) for all ages, 0.05 (0.04–0.05) for <5 years of age, 0.08 (0.06–0.09) for 5–17 years, 0.06 (0.05–0.08) for 18–49 years, 0.06 (0.05–0.07) for 50–64 years, and 0.05 (0.04–0.06) for ≥65 years. PCV10/13 use in infant immunization programs was followed by a 95% reduction in ST1 IPD in all ages after approximately 6 years. Limited data availability from the highest ST1 disease burden countries using a 3 + 0 schedule constrains generalizability and data from these settings are needed. MDPI 2021-03-27 /pmc/articles/PMC8066231/ /pubmed/33801760 http://dx.doi.org/10.3390/microorganisms9040696 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Bennett, Julia C. Hetrich, Marissa K. Garcia Quesada, Maria Sinkevitch, Jenna N. Deloria Knoll, Maria Feikin, Daniel R. Zeger, Scott L. Kagucia, Eunice W. Cohen, Adam L. Ampofo, Krow Brandileone, Maria-Cristina C. Bruden, Dana Camilli, Romina Castilla, Jesús Chan, Guanhao Cook, Heather Cornick, Jennifer E. Dagan, Ron Dalby, Tine Danis, Kostas de Miguel, Sara De Wals, Philippe Desmet, Stefanie Georgakopoulou, Theano Gilkison, Charlotte Grgic-Vitek, Marta Hammitt, Laura L. Hilty, Markus Ho, Pak-Leung Jayasinghe, Sanjay Kellner, James D. Kleynhans, Jackie Knol, Mirjam J. Kozakova, Jana Kristinsson, Karl G. Ladhani, Shamez N. MacDonald, Laura Mackenzie, Grant A. Mad’arová, Lucia McGeer, Allison Mereckiene, Jolita Morfeldt, Eva Mungun, Tuya Muñoz-Almagro, Carmen Nuorti, J. Pekka Paragi, Metka Pilishvili, Tamara Puentes, Rodrigo Saha, Samir K. Sahu Khan, Aalisha Savrasova, Larisa Scott, J. Anthony Skoczyńska, Anna Suga, Shigeru van der Linden, Mark Verani, Jennifer R. von Gottberg, Anne Winje, Brita A. Yildirim, Inci Zerouali, Khalid Hayford, Kyla Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project |
title | Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project |
title_full | Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project |
title_fullStr | Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project |
title_full_unstemmed | Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project |
title_short | Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project |
title_sort | changes in invasive pneumococcal disease caused by streptococcus pneumoniae serotype 1 following introduction of pcv10 and pcv13: findings from the pserenade project |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066231/ https://www.ncbi.nlm.nih.gov/pubmed/33801760 http://dx.doi.org/10.3390/microorganisms9040696 |
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