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Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds
Environmental factors, particularly diet, are considered central to the pathogenesis of the inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis. In particular, the Westernization of diet, characterized by high intake of animal protein, saturated fat, and refined carbohydrates,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066255/ https://www.ncbi.nlm.nih.gov/pubmed/33916612 http://dx.doi.org/10.3390/foods10040774 |
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author | Basson, Abigail Raffner Ahmed, Saleh Almutairi, Rawan Seo, Brian Cominelli, Fabio |
author_facet | Basson, Abigail Raffner Ahmed, Saleh Almutairi, Rawan Seo, Brian Cominelli, Fabio |
author_sort | Basson, Abigail Raffner |
collection | PubMed |
description | Environmental factors, particularly diet, are considered central to the pathogenesis of the inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis. In particular, the Westernization of diet, characterized by high intake of animal protein, saturated fat, and refined carbohydrates, has been shown to contribute to the development and progression of IBD. During the last decade, soybean, as well as soy-derived bioactive compounds (e.g., isoflavones, phytosterols, Bowman-Birk inhibitors) have been increasingly investigated because of their anti-inflammatory properties in animal models of IBD. Herein we provide a scoping review of the most studied disease mechanisms associated with disease induction and progression in IBD rodent models after feeding of either the whole food or a bioactive present in soybean. |
format | Online Article Text |
id | pubmed-8066255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80662552021-04-25 Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds Basson, Abigail Raffner Ahmed, Saleh Almutairi, Rawan Seo, Brian Cominelli, Fabio Foods Review Environmental factors, particularly diet, are considered central to the pathogenesis of the inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis. In particular, the Westernization of diet, characterized by high intake of animal protein, saturated fat, and refined carbohydrates, has been shown to contribute to the development and progression of IBD. During the last decade, soybean, as well as soy-derived bioactive compounds (e.g., isoflavones, phytosterols, Bowman-Birk inhibitors) have been increasingly investigated because of their anti-inflammatory properties in animal models of IBD. Herein we provide a scoping review of the most studied disease mechanisms associated with disease induction and progression in IBD rodent models after feeding of either the whole food or a bioactive present in soybean. MDPI 2021-04-04 /pmc/articles/PMC8066255/ /pubmed/33916612 http://dx.doi.org/10.3390/foods10040774 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Basson, Abigail Raffner Ahmed, Saleh Almutairi, Rawan Seo, Brian Cominelli, Fabio Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds |
title | Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds |
title_full | Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds |
title_fullStr | Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds |
title_full_unstemmed | Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds |
title_short | Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds |
title_sort | regulation of intestinal inflammation by soybean and soy-derived compounds |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066255/ https://www.ncbi.nlm.nih.gov/pubmed/33916612 http://dx.doi.org/10.3390/foods10040774 |
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