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Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms
SIMPLE SUMMARY: In four neuroendocrine tumor (NET) centers, we structurally assessed the involvement of the central nervous system with a focus on leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms. We precisely evaluated the clinical pathological criteria, symptoms, therap...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066280/ https://www.ncbi.nlm.nih.gov/pubmed/33800581 http://dx.doi.org/10.3390/biology10040277 |
Sumario: | SIMPLE SUMMARY: In four neuroendocrine tumor (NET) centers, we structurally assessed the involvement of the central nervous system with a focus on leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms. We precisely evaluated the clinical pathological criteria, symptoms, therapy, and outcomes. LC is associated with a poor prognosis but not attributed to special patient characteristics. There is currently an unmet medical need for an optimal treatment strategy for neuroendocrine neoplasm (NEN) patients with LC. In some cases, MRI of the brain and spine might be implemented in the diagnostic workup. ABSTRACT: Central nervous system (CNS) involvement by paraneoplastic syndromes, brain metastases, or leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms (NEN) has only been described in individual case reports. We evaluated patients with LC in four neuroendocrine tumor (NET) centers (Halle/Saale, Hamburg, Heidelberg, and Marburg) and characterized them clinically. In the study, 17 patients with a LC were defined with respect to diagnosis, clinic, and therapy. The prognosis of a LC is very poor, with 10 months in median overall survival (mOS). This is reflected by an even worse course in neuroendocrine carcinoma (NEC) G3 Ki-67 >55%, with a mOS of 2 months. Motor and sensory deficits together with vigilance abnormalities were common symptoms. In most cases, targeted radiation or temozolomide therapy was used against the LC. LC appears to be similarly devastating to brain metastases in NEN patients. Therefore, the indication for CNS imaging should be discussed in certain cases. |
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