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Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms

SIMPLE SUMMARY: In four neuroendocrine tumor (NET) centers, we structurally assessed the involvement of the central nervous system with a focus on leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms. We precisely evaluated the clinical pathological criteria, symptoms, therap...

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Autores principales: Apostolidis, Leonidas, Schrader, Jörg, Jann, Henning, Rinke, Anja, Krug, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066280/
https://www.ncbi.nlm.nih.gov/pubmed/33800581
http://dx.doi.org/10.3390/biology10040277
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author Apostolidis, Leonidas
Schrader, Jörg
Jann, Henning
Rinke, Anja
Krug, Sebastian
author_facet Apostolidis, Leonidas
Schrader, Jörg
Jann, Henning
Rinke, Anja
Krug, Sebastian
author_sort Apostolidis, Leonidas
collection PubMed
description SIMPLE SUMMARY: In four neuroendocrine tumor (NET) centers, we structurally assessed the involvement of the central nervous system with a focus on leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms. We precisely evaluated the clinical pathological criteria, symptoms, therapy, and outcomes. LC is associated with a poor prognosis but not attributed to special patient characteristics. There is currently an unmet medical need for an optimal treatment strategy for neuroendocrine neoplasm (NEN) patients with LC. In some cases, MRI of the brain and spine might be implemented in the diagnostic workup. ABSTRACT: Central nervous system (CNS) involvement by paraneoplastic syndromes, brain metastases, or leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms (NEN) has only been described in individual case reports. We evaluated patients with LC in four neuroendocrine tumor (NET) centers (Halle/Saale, Hamburg, Heidelberg, and Marburg) and characterized them clinically. In the study, 17 patients with a LC were defined with respect to diagnosis, clinic, and therapy. The prognosis of a LC is very poor, with 10 months in median overall survival (mOS). This is reflected by an even worse course in neuroendocrine carcinoma (NEC) G3 Ki-67 >55%, with a mOS of 2 months. Motor and sensory deficits together with vigilance abnormalities were common symptoms. In most cases, targeted radiation or temozolomide therapy was used against the LC. LC appears to be similarly devastating to brain metastases in NEN patients. Therefore, the indication for CNS imaging should be discussed in certain cases.
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spelling pubmed-80662802021-04-25 Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms Apostolidis, Leonidas Schrader, Jörg Jann, Henning Rinke, Anja Krug, Sebastian Biology (Basel) Article SIMPLE SUMMARY: In four neuroendocrine tumor (NET) centers, we structurally assessed the involvement of the central nervous system with a focus on leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms. We precisely evaluated the clinical pathological criteria, symptoms, therapy, and outcomes. LC is associated with a poor prognosis but not attributed to special patient characteristics. There is currently an unmet medical need for an optimal treatment strategy for neuroendocrine neoplasm (NEN) patients with LC. In some cases, MRI of the brain and spine might be implemented in the diagnostic workup. ABSTRACT: Central nervous system (CNS) involvement by paraneoplastic syndromes, brain metastases, or leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms (NEN) has only been described in individual case reports. We evaluated patients with LC in four neuroendocrine tumor (NET) centers (Halle/Saale, Hamburg, Heidelberg, and Marburg) and characterized them clinically. In the study, 17 patients with a LC were defined with respect to diagnosis, clinic, and therapy. The prognosis of a LC is very poor, with 10 months in median overall survival (mOS). This is reflected by an even worse course in neuroendocrine carcinoma (NEC) G3 Ki-67 >55%, with a mOS of 2 months. Motor and sensory deficits together with vigilance abnormalities were common symptoms. In most cases, targeted radiation or temozolomide therapy was used against the LC. LC appears to be similarly devastating to brain metastases in NEN patients. Therefore, the indication for CNS imaging should be discussed in certain cases. MDPI 2021-03-28 /pmc/articles/PMC8066280/ /pubmed/33800581 http://dx.doi.org/10.3390/biology10040277 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Apostolidis, Leonidas
Schrader, Jörg
Jann, Henning
Rinke, Anja
Krug, Sebastian
Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms
title Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms
title_full Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms
title_fullStr Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms
title_full_unstemmed Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms
title_short Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms
title_sort leptomeningeal carcinomatosis: a clinical dilemma in neuroendocrine neoplasms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066280/
https://www.ncbi.nlm.nih.gov/pubmed/33800581
http://dx.doi.org/10.3390/biology10040277
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