Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach

A 3-months-old male domestic kitten was referred for repeated seizures. Analysis revealed Cryptococcus neoformans. Levetiracetam and fluconazole were administered without significant clinical improvements and without negativization. Hypothesizing resistance, therapy was switched to amphotericin B. S...

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Detalles Bibliográficos
Autores principales: Vercelli, Cristina, Peano, Andrea, Piovano, Giulia, Corona, Antonio, Gambino, Graziana, Re, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066322/
https://www.ncbi.nlm.nih.gov/pubmed/33912382
http://dx.doi.org/10.1016/j.mmcr.2021.04.001
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author Vercelli, Cristina
Peano, Andrea
Piovano, Giulia
Corona, Antonio
Gambino, Graziana
Re, Giovanni
author_facet Vercelli, Cristina
Peano, Andrea
Piovano, Giulia
Corona, Antonio
Gambino, Graziana
Re, Giovanni
author_sort Vercelli, Cristina
collection PubMed
description A 3-months-old male domestic kitten was referred for repeated seizures. Analysis revealed Cryptococcus neoformans. Levetiracetam and fluconazole were administered without significant clinical improvements and without negativization. Hypothesizing resistance, therapy was switched to amphotericin B. Seizure disappeared. Haematological controls highlighted transitory increasing of CK, BUN, ALP and cholesterol. PCR repeated two weeks after the treatment was negative for Cryptococcus neoformans. Nowadays the cat is 5 years old, and no seizures occurred since the age of 5 months.
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spelling pubmed-80663222021-04-27 Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach Vercelli, Cristina Peano, Andrea Piovano, Giulia Corona, Antonio Gambino, Graziana Re, Giovanni Med Mycol Case Rep Case Report A 3-months-old male domestic kitten was referred for repeated seizures. Analysis revealed Cryptococcus neoformans. Levetiracetam and fluconazole were administered without significant clinical improvements and without negativization. Hypothesizing resistance, therapy was switched to amphotericin B. Seizure disappeared. Haematological controls highlighted transitory increasing of CK, BUN, ALP and cholesterol. PCR repeated two weeks after the treatment was negative for Cryptococcus neoformans. Nowadays the cat is 5 years old, and no seizures occurred since the age of 5 months. Elsevier 2021-04-13 /pmc/articles/PMC8066322/ /pubmed/33912382 http://dx.doi.org/10.1016/j.mmcr.2021.04.001 Text en © 2021 The Authors. Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Vercelli, Cristina
Peano, Andrea
Piovano, Giulia
Corona, Antonio
Gambino, Graziana
Re, Giovanni
Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach
title Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach
title_full Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach
title_fullStr Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach
title_full_unstemmed Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach
title_short Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach
title_sort diagnostic and therapeutic management of cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066322/
https://www.ncbi.nlm.nih.gov/pubmed/33912382
http://dx.doi.org/10.1016/j.mmcr.2021.04.001
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