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Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women

Risk factors for the different human papillomavirus (HPV) genotypes are not well understood, although the risk of cancer is known to vary among them. Our aim was to evaluate the association of diverse behavioral and reproductive factors with genotype-specific HPV prevalence among 879 unvaccinated wo...

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Autores principales: Bergqvist, Laura, Kalliala, Ilkka, Aro, Karoliina, Auvinen, Eeva, Jakobsson, Maija, Kiviharju, Mari, Virtanen, Seppo, Dillner, Joakim, Nieminen, Pekka, Louvanto, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066411/
https://www.ncbi.nlm.nih.gov/pubmed/33918429
http://dx.doi.org/10.3390/microorganisms9040750
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author Bergqvist, Laura
Kalliala, Ilkka
Aro, Karoliina
Auvinen, Eeva
Jakobsson, Maija
Kiviharju, Mari
Virtanen, Seppo
Dillner, Joakim
Nieminen, Pekka
Louvanto, Karolina
author_facet Bergqvist, Laura
Kalliala, Ilkka
Aro, Karoliina
Auvinen, Eeva
Jakobsson, Maija
Kiviharju, Mari
Virtanen, Seppo
Dillner, Joakim
Nieminen, Pekka
Louvanto, Karolina
author_sort Bergqvist, Laura
collection PubMed
description Risk factors for the different human papillomavirus (HPV) genotypes are not well understood, although the risk of cancer is known to vary among them. Our aim was to evaluate the association of diverse behavioral and reproductive factors with genotype-specific HPV prevalence among 879 unvaccinated women aged 18–75 years referred to the colposcopy clinic at Helsinki University Hospital in Finland. Cervical swabs for HPV genotyping were collected in the first visit and assessed for 34 high-risk (hr) and low-risk (lr) HPV genotypes. Participants completed a questionnaire on behavioral, reproductive, and lifestyle factors. Differences in genotype-specific HPV prevalence were analyzed overall and in age groups using binary logistic regression. Smoking was associated with higher prevalence in HPV16 compared with other hrHPV genotypes together with decreasing age, being highest among younger women <30 years old, odds ratio (OR) 3.74 (95% CI 1.42–9.88). The later the sexual debut, the more it seemed to protect from HPV16 infection. The best protection was achieved when the sexual debut took place at >20 years of age, with an OR of 0.43 (95% CI 0.23–0.83). This association was not seen with other hrHPV genotypes. Methods of contraception seemed not to have an effect on hrHPV positivity, regardless of the HPV genotype. The genotype specific hrHPV prevalence differs, depending on behavioral factors, especially among younger women referred to colposcopy.
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spelling pubmed-80664112021-04-25 Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women Bergqvist, Laura Kalliala, Ilkka Aro, Karoliina Auvinen, Eeva Jakobsson, Maija Kiviharju, Mari Virtanen, Seppo Dillner, Joakim Nieminen, Pekka Louvanto, Karolina Microorganisms Article Risk factors for the different human papillomavirus (HPV) genotypes are not well understood, although the risk of cancer is known to vary among them. Our aim was to evaluate the association of diverse behavioral and reproductive factors with genotype-specific HPV prevalence among 879 unvaccinated women aged 18–75 years referred to the colposcopy clinic at Helsinki University Hospital in Finland. Cervical swabs for HPV genotyping were collected in the first visit and assessed for 34 high-risk (hr) and low-risk (lr) HPV genotypes. Participants completed a questionnaire on behavioral, reproductive, and lifestyle factors. Differences in genotype-specific HPV prevalence were analyzed overall and in age groups using binary logistic regression. Smoking was associated with higher prevalence in HPV16 compared with other hrHPV genotypes together with decreasing age, being highest among younger women <30 years old, odds ratio (OR) 3.74 (95% CI 1.42–9.88). The later the sexual debut, the more it seemed to protect from HPV16 infection. The best protection was achieved when the sexual debut took place at >20 years of age, with an OR of 0.43 (95% CI 0.23–0.83). This association was not seen with other hrHPV genotypes. Methods of contraception seemed not to have an effect on hrHPV positivity, regardless of the HPV genotype. The genotype specific hrHPV prevalence differs, depending on behavioral factors, especially among younger women referred to colposcopy. MDPI 2021-04-02 /pmc/articles/PMC8066411/ /pubmed/33918429 http://dx.doi.org/10.3390/microorganisms9040750 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bergqvist, Laura
Kalliala, Ilkka
Aro, Karoliina
Auvinen, Eeva
Jakobsson, Maija
Kiviharju, Mari
Virtanen, Seppo
Dillner, Joakim
Nieminen, Pekka
Louvanto, Karolina
Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women
title Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women
title_full Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women
title_fullStr Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women
title_full_unstemmed Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women
title_short Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women
title_sort distribution of hpv genotypes differs depending on behavioural factors among young women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066411/
https://www.ncbi.nlm.nih.gov/pubmed/33918429
http://dx.doi.org/10.3390/microorganisms9040750
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