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Combined epigenetic/genetic study identified an ALS age of onset modifier

Age at onset of amyotrophic lateral sclerosis (ALS) is highly variable (eg, 27–74 years in carriers of the G(4)C(2)-expansion in C9orf72). It might be influenced by environmental and genetic factors via the modulation of DNA methylation (DNAm) at CpG-sites. Hence, we combined an epigenetic and genet...

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Detalles Bibliográficos
Autores principales:	Zhang, Ming, Xi, Zhengrui, Saez-Atienzar, Sara, Chia, Ruth, Moreno, Danielle, Sato, Christine, Montazer Haghighi, Mahdi, Traynor, Bryan J., Zinman, Lorne, Rogaeva, Ekaterina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066440/ https://www.ncbi.nlm.nih.gov/pubmed/33892821 http://dx.doi.org/10.1186/s40478-021-01183-w

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