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Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1

BubR1 is an essential component of the spindle assembly checkpoint (SAC) during mitosis where it functions to prevent anaphase onset to ensure proper chromosome alignment and kinetochore-microtubule attachment. Loss or mutation of BubR1 results in aneuploidy that precedes various potential pathologi...

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Detalles Bibliográficos
Autores principales:	Bloom, Celia R., North, Brian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066494/ https://www.ncbi.nlm.nih.gov/pubmed/33892776 http://dx.doi.org/10.1186/s13578-021-00589-2

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