Cargando…

Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

Hepatic fibrosis is the primary predictor of mortality in patients with non-alcoholic steatohepatitis (NASH). In this process, the activated hepatic stellate cells (HSCs) constitute the principal cells responsible for the deposition of a fibrous extracellular matrix, thereby driving the hepatic scar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zisser, Alexandra, Ipsen, David H., Tveden-Nyborg, Pernille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066583/ https://www.ncbi.nlm.nih.gov/pubmed/33807461 http://dx.doi.org/10.3390/biomedicines9040365

Ejemplares similares

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
por: Ipsen, David Højland, et al.
Publicado: (2018)

Extracellular Vesicles as Drivers of Non-Alcoholic Fatty Liver Disease: Small Particles with Big Impact
por: Ipsen, David Højland, et al.
Publicado: (2021)

Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig
por: Skat-Rørdam, Josephine, et al.
Publicado: (2021)

Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation
por: Klaebel, Julie Hviid, et al.
Publicado: (2020)

A role of peroxisome proliferator‐activated receptor γ in non‐alcoholic fatty liver disease
por: Skat‐Rørdam, Josephine, et al.
Publicado: (2019)

Does Vitamin C Deficiency Promote Fatty Liver Disease Development?
por: Ipsen, David Højland, et al.
Publicado: (2014)

Atorvastatin and Vitamin E Accelerates NASH Resolution by Dietary Intervention in a Preclinical Guinea Pig Model
por: Klaebel, Julie Hviid, et al.
Publicado: (2019)

Hepatic Stellate Cell-Immune Interactions in NASH
por: Carter, James K., et al.
Publicado: (2022)

Transcriptional regulation of Hepatic Stellate Cell activation in NASH
por: Marcher, Ann-Britt, et al.
Publicado: (2019)

Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis
por: Pedersen, Kamilla, et al.
Publicado: (2023)

Vitamin C Deficiency in the Young Brain—Findings from Experimental Animal Models †
por: Tveden-Nyborg, Pernille
Publicado: (2021)

Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation
por: Nagasaki, Atsuhiro, et al.
Publicado: (2020)

The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs
por: Ipsen, D. H., et al.
Publicado: (2021)

The Pharmacokinetics of Vitamin C
por: Lykkesfeldt, Jens, et al.
Publicado: (2019)

Differential Effects of Dietary Components on Glucose Intolerance and Non-Alcoholic Steatohepatitis
por: Skat-Rørdam, Josephine, et al.
Publicado: (2021)

Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model
por: Skat-Rørdam, Josephine, et al.
Publicado: (2021)

Differentially expressed mRNAs and lncRNAs shared between activated human hepatic stellate cells and nash fibrosis
por: Gerhard, Glenn S., et al.
Publicado: (2020)

Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH
por: Lee, Su-Yeon, et al.
Publicado: (2022)

Regulation of Vitamin C Homeostasis during Deficiency
por: Lindblad, Maiken, et al.
Publicado: (2013)

Does Vitamin C Deficiency Affect Cognitive Development and Function?
por: Hansen, Stine Normann, et al.
Publicado: (2014)

l-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs
por: Frikke-Schmidt, Henriette, et al.
Publicado: (2015)

Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice
por: Chung, Kyoung-Jin, et al.
Publicado: (2023)

Cholesterol Induces Oxidative Stress, Mitochondrial Damage and Death in Hepatic Stellate Cells to Mitigate Liver Fibrosis in Mice Model of NASH
por: Rauchbach, Einat, et al.
Publicado: (2022)

Targeted Drug Delivery to Hepatic Stellate Cells for the Treatment of Liver Fibrosis
por: Chen, Zhijin, et al.
Publicado: (2019)

Novel oral SPT inhibitor CH5169356 inhibits hepatic stellate cell activation and ameliorates hepatic fibrosis in mouse models of non‐alcoholic steatohepatitis (NASH)
por: Hada, Natsuko, et al.
Publicado: (2023)

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
por: Hall, Katherine C., et al.
Publicado: (2019)

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis
por: Schon, Hans-Theo, et al.
Publicado: (2016)

Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo
por: Tseng, Tsui-Hwa, et al.
Publicado: (2016)

MicroRNA-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2
por: Wu, Jun-Cheng, et al.
Publicado: (2019)

IL-22 alleviates the fibrosis of hepatic stellate cells via the inactivation of NLRP3 inflammasome signaling
por: Xing, Zhuyun, et al.
Publicado: (2021)

Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression
por: Paidi, Maya D., et al.
Publicado: (2014)

Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains
por: Paidi, Maya D., et al.
Publicado: (2014)

Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders
por: Frederiksen, Henriette Reventlow, et al.
Publicado: (2021)

Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging
por: Li, Dan, et al.
Publicado: (2015)

Galangin delivered by retinoic acid-modified nanoparticles targeted hepatic stellate cells for the treatment of hepatic fibrosis
por: Xiong, Yuanguo, et al.
Publicado: (2023)

High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs
por: Ipsen, David Højland, et al.
Publicado: (2016)

Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis
por: Yin, Xiaochun, et al.
Publicado: (2022)

Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death
por: Albadawy, Reda, et al.
Publicado: (2022)

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression
por: Wijayasiri, Pramudi, et al.
Publicado: (2022)

Role of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression
por: Ye, Bingyu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kr2mrafqktr4o23clsn7rrp0kr