New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.

Three new andrastin-type meroterpenoids penimeroterpenoids A–C (1–3) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Mag...

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Autores principales: Ren, Jinwei, Huo, Ruiyun, Liu, Gaoran, Liu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066695/
https://www.ncbi.nlm.nih.gov/pubmed/33801640
http://dx.doi.org/10.3390/md19040189
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author Ren, Jinwei
Huo, Ruiyun
Liu, Gaoran
Liu, Ling
author_facet Ren, Jinwei
Huo, Ruiyun
Liu, Gaoran
Liu, Ling
author_sort Ren, Jinwei
collection PubMed
description Three new andrastin-type meroterpenoids penimeroterpenoids A–C (1–3) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of 1–3 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines.
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spelling pubmed-80666952021-04-25 New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp. Ren, Jinwei Huo, Ruiyun Liu, Gaoran Liu, Ling Mar Drugs Article Three new andrastin-type meroterpenoids penimeroterpenoids A–C (1–3) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of 1–3 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines. MDPI 2021-03-27 /pmc/articles/PMC8066695/ /pubmed/33801640 http://dx.doi.org/10.3390/md19040189 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Ren, Jinwei
Huo, Ruiyun
Liu, Gaoran
Liu, Ling
New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
title New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
title_full New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
title_fullStr New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
title_full_unstemmed New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
title_short New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
title_sort new andrastin-type meroterpenoids from the marine-derived fungus penicillium sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066695/
https://www.ncbi.nlm.nih.gov/pubmed/33801640
http://dx.doi.org/10.3390/md19040189
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