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Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States

Molecular cluster detection analyzes HIV sequences to identify rapid HIV transmission and inform public health responses. We describe changes in the capability to detect molecular clusters and in geographic variation in transmission dynamics. We examined the reporting completeness of HIV-1 polymeras...

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Autores principales: Oster, Alexandra M., Panneer, Nivedha, Lyss, Sheryl B., McClung, R. Paul, Watson, Meg, Saduvala, Neeraja, Ocfemia, M. Cheryl Bañez, Linley, Laurie, Switzer, William M., Wertheim, Joel O., Campbell, Ellsworth, Hernandez, Angela L., France, Anne Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066706/
https://www.ncbi.nlm.nih.gov/pubmed/33808053
http://dx.doi.org/10.3390/v13040577
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author Oster, Alexandra M.
Panneer, Nivedha
Lyss, Sheryl B.
McClung, R. Paul
Watson, Meg
Saduvala, Neeraja
Ocfemia, M. Cheryl Bañez
Linley, Laurie
Switzer, William M.
Wertheim, Joel O.
Campbell, Ellsworth
Hernandez, Angela L.
France, Anne Marie
author_facet Oster, Alexandra M.
Panneer, Nivedha
Lyss, Sheryl B.
McClung, R. Paul
Watson, Meg
Saduvala, Neeraja
Ocfemia, M. Cheryl Bañez
Linley, Laurie
Switzer, William M.
Wertheim, Joel O.
Campbell, Ellsworth
Hernandez, Angela L.
France, Anne Marie
author_sort Oster, Alexandra M.
collection PubMed
description Molecular cluster detection analyzes HIV sequences to identify rapid HIV transmission and inform public health responses. We describe changes in the capability to detect molecular clusters and in geographic variation in transmission dynamics. We examined the reporting completeness of HIV-1 polymerase sequences in quarterly National HIV Surveillance System datasets from December 2015 to December 2019. Priority clusters were identified quarterly. To understand populations recently affected by rapid transmission, we described the transmission risk and race/ethnicity of people in clusters first detected in 2018–2019. During December 2015 to December 2019, national sequence completeness increased from 26% to 45%. Of the 1212 people in the 136 clusters first detected in 2018–2019, 69% were men who have sex with men (MSM) and 11% were people who inject drugs (PWID). State-by-state analysis showed substantial variation in transmission risk and racial/ethnic groups in clusters of rapid transmission. HIV sequence reporting has increased nationwide. Molecular cluster analysis identifies rapid transmission in varied populations and identifies emerging patterns of rapid transmission in specific population groups, such as PWID, who, in 2015–2016, comprised only 1% of people in such molecular clusters. These data can guide efforts to focus, tailor, and scale up prevention and care services for these populations.
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spelling pubmed-80667062021-04-25 Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States Oster, Alexandra M. Panneer, Nivedha Lyss, Sheryl B. McClung, R. Paul Watson, Meg Saduvala, Neeraja Ocfemia, M. Cheryl Bañez Linley, Laurie Switzer, William M. Wertheim, Joel O. Campbell, Ellsworth Hernandez, Angela L. France, Anne Marie Viruses Article Molecular cluster detection analyzes HIV sequences to identify rapid HIV transmission and inform public health responses. We describe changes in the capability to detect molecular clusters and in geographic variation in transmission dynamics. We examined the reporting completeness of HIV-1 polymerase sequences in quarterly National HIV Surveillance System datasets from December 2015 to December 2019. Priority clusters were identified quarterly. To understand populations recently affected by rapid transmission, we described the transmission risk and race/ethnicity of people in clusters first detected in 2018–2019. During December 2015 to December 2019, national sequence completeness increased from 26% to 45%. Of the 1212 people in the 136 clusters first detected in 2018–2019, 69% were men who have sex with men (MSM) and 11% were people who inject drugs (PWID). State-by-state analysis showed substantial variation in transmission risk and racial/ethnic groups in clusters of rapid transmission. HIV sequence reporting has increased nationwide. Molecular cluster analysis identifies rapid transmission in varied populations and identifies emerging patterns of rapid transmission in specific population groups, such as PWID, who, in 2015–2016, comprised only 1% of people in such molecular clusters. These data can guide efforts to focus, tailor, and scale up prevention and care services for these populations. MDPI 2021-03-30 /pmc/articles/PMC8066706/ /pubmed/33808053 http://dx.doi.org/10.3390/v13040577 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Oster, Alexandra M.
Panneer, Nivedha
Lyss, Sheryl B.
McClung, R. Paul
Watson, Meg
Saduvala, Neeraja
Ocfemia, M. Cheryl Bañez
Linley, Laurie
Switzer, William M.
Wertheim, Joel O.
Campbell, Ellsworth
Hernandez, Angela L.
France, Anne Marie
Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States
title Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States
title_full Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States
title_fullStr Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States
title_full_unstemmed Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States
title_short Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations—United States
title_sort increasing capacity to detect clusters of rapid hiv transmission in varied populations—united states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066706/
https://www.ncbi.nlm.nih.gov/pubmed/33808053
http://dx.doi.org/10.3390/v13040577
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