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Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms
Patients need medications at a dosage suited to their physiological characteristics. Three-dimensional printing (3DP) technology by fused-filament fabrication (FFF) is a solution for manufacturing medication on demand. The aim of this work was to identify important parameters for the production of r...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066748/ https://www.ncbi.nlm.nih.gov/pubmed/33807390 http://dx.doi.org/10.3390/pharmaceutics13040472 |
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author | Roulon, Stéphane Soulairol, Ian Lavastre, Valérie Payre, Nicolas Cazes, Maxime Delbreilh, Laurent Alié, Jean |
author_facet | Roulon, Stéphane Soulairol, Ian Lavastre, Valérie Payre, Nicolas Cazes, Maxime Delbreilh, Laurent Alié, Jean |
author_sort | Roulon, Stéphane |
collection | PubMed |
description | Patients need medications at a dosage suited to their physiological characteristics. Three-dimensional printing (3DP) technology by fused-filament fabrication (FFF) is a solution for manufacturing medication on demand. The aim of this work was to identify important parameters for the production of reproducible filament batches used by 3DP for oral formulations. Amiodarone hydrochloride, an antiarrhythmic and insoluble drug, was chosen as a model drug because of dosage adaptation need in children. Polyethylene oxide (PEO) filaments containing amiodarone hydrochloride were produced by hot-melt extrusion (HME). Different formulation storage conditions were investigated. For all formulations, the physical form of the drug following HME and fused-deposition modeling (FDM) 3D-printing processes were assessed using thermal analysis and X-ray powder diffraction (XRPD). Filament mechanical properties, linear mass density and surface roughness, were investigated by, respectively, 3-point bending, weighing, and scanning electron microscopy (SEM). Analysis results showed that the formulation storage condition before HME-modified filament linear mass density and, therefore, the oral forms masses from a batch to another. To obtain constant filament apparent density, it has been shown that a constant and reproducible drying condition is required to produce oral forms with constant mass. |
format | Online Article Text |
id | pubmed-8066748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80667482021-04-25 Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms Roulon, Stéphane Soulairol, Ian Lavastre, Valérie Payre, Nicolas Cazes, Maxime Delbreilh, Laurent Alié, Jean Pharmaceutics Article Patients need medications at a dosage suited to their physiological characteristics. Three-dimensional printing (3DP) technology by fused-filament fabrication (FFF) is a solution for manufacturing medication on demand. The aim of this work was to identify important parameters for the production of reproducible filament batches used by 3DP for oral formulations. Amiodarone hydrochloride, an antiarrhythmic and insoluble drug, was chosen as a model drug because of dosage adaptation need in children. Polyethylene oxide (PEO) filaments containing amiodarone hydrochloride were produced by hot-melt extrusion (HME). Different formulation storage conditions were investigated. For all formulations, the physical form of the drug following HME and fused-deposition modeling (FDM) 3D-printing processes were assessed using thermal analysis and X-ray powder diffraction (XRPD). Filament mechanical properties, linear mass density and surface roughness, were investigated by, respectively, 3-point bending, weighing, and scanning electron microscopy (SEM). Analysis results showed that the formulation storage condition before HME-modified filament linear mass density and, therefore, the oral forms masses from a batch to another. To obtain constant filament apparent density, it has been shown that a constant and reproducible drying condition is required to produce oral forms with constant mass. MDPI 2021-03-31 /pmc/articles/PMC8066748/ /pubmed/33807390 http://dx.doi.org/10.3390/pharmaceutics13040472 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Roulon, Stéphane Soulairol, Ian Lavastre, Valérie Payre, Nicolas Cazes, Maxime Delbreilh, Laurent Alié, Jean Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms |
title | Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms |
title_full | Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms |
title_fullStr | Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms |
title_full_unstemmed | Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms |
title_short | Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms |
title_sort | production of reproducible filament batches for the fabrication of 3d printed oral forms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066748/ https://www.ncbi.nlm.nih.gov/pubmed/33807390 http://dx.doi.org/10.3390/pharmaceutics13040472 |
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