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Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms

Patients need medications at a dosage suited to their physiological characteristics. Three-dimensional printing (3DP) technology by fused-filament fabrication (FFF) is a solution for manufacturing medication on demand. The aim of this work was to identify important parameters for the production of r...

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Autores principales: Roulon, Stéphane, Soulairol, Ian, Lavastre, Valérie, Payre, Nicolas, Cazes, Maxime, Delbreilh, Laurent, Alié, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066748/
https://www.ncbi.nlm.nih.gov/pubmed/33807390
http://dx.doi.org/10.3390/pharmaceutics13040472
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author Roulon, Stéphane
Soulairol, Ian
Lavastre, Valérie
Payre, Nicolas
Cazes, Maxime
Delbreilh, Laurent
Alié, Jean
author_facet Roulon, Stéphane
Soulairol, Ian
Lavastre, Valérie
Payre, Nicolas
Cazes, Maxime
Delbreilh, Laurent
Alié, Jean
author_sort Roulon, Stéphane
collection PubMed
description Patients need medications at a dosage suited to their physiological characteristics. Three-dimensional printing (3DP) technology by fused-filament fabrication (FFF) is a solution for manufacturing medication on demand. The aim of this work was to identify important parameters for the production of reproducible filament batches used by 3DP for oral formulations. Amiodarone hydrochloride, an antiarrhythmic and insoluble drug, was chosen as a model drug because of dosage adaptation need in children. Polyethylene oxide (PEO) filaments containing amiodarone hydrochloride were produced by hot-melt extrusion (HME). Different formulation storage conditions were investigated. For all formulations, the physical form of the drug following HME and fused-deposition modeling (FDM) 3D-printing processes were assessed using thermal analysis and X-ray powder diffraction (XRPD). Filament mechanical properties, linear mass density and surface roughness, were investigated by, respectively, 3-point bending, weighing, and scanning electron microscopy (SEM). Analysis results showed that the formulation storage condition before HME-modified filament linear mass density and, therefore, the oral forms masses from a batch to another. To obtain constant filament apparent density, it has been shown that a constant and reproducible drying condition is required to produce oral forms with constant mass.
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spelling pubmed-80667482021-04-25 Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms Roulon, Stéphane Soulairol, Ian Lavastre, Valérie Payre, Nicolas Cazes, Maxime Delbreilh, Laurent Alié, Jean Pharmaceutics Article Patients need medications at a dosage suited to their physiological characteristics. Three-dimensional printing (3DP) technology by fused-filament fabrication (FFF) is a solution for manufacturing medication on demand. The aim of this work was to identify important parameters for the production of reproducible filament batches used by 3DP for oral formulations. Amiodarone hydrochloride, an antiarrhythmic and insoluble drug, was chosen as a model drug because of dosage adaptation need in children. Polyethylene oxide (PEO) filaments containing amiodarone hydrochloride were produced by hot-melt extrusion (HME). Different formulation storage conditions were investigated. For all formulations, the physical form of the drug following HME and fused-deposition modeling (FDM) 3D-printing processes were assessed using thermal analysis and X-ray powder diffraction (XRPD). Filament mechanical properties, linear mass density and surface roughness, were investigated by, respectively, 3-point bending, weighing, and scanning electron microscopy (SEM). Analysis results showed that the formulation storage condition before HME-modified filament linear mass density and, therefore, the oral forms masses from a batch to another. To obtain constant filament apparent density, it has been shown that a constant and reproducible drying condition is required to produce oral forms with constant mass. MDPI 2021-03-31 /pmc/articles/PMC8066748/ /pubmed/33807390 http://dx.doi.org/10.3390/pharmaceutics13040472 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Roulon, Stéphane
Soulairol, Ian
Lavastre, Valérie
Payre, Nicolas
Cazes, Maxime
Delbreilh, Laurent
Alié, Jean
Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms
title Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms
title_full Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms
title_fullStr Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms
title_full_unstemmed Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms
title_short Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms
title_sort production of reproducible filament batches for the fabrication of 3d printed oral forms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066748/
https://www.ncbi.nlm.nih.gov/pubmed/33807390
http://dx.doi.org/10.3390/pharmaceutics13040472
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