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Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus
As part of the first randomized double-blind trial of deep brain stimulation (DBS) of the globus pallidus (GPi) in Tourette syndrome, we examined the effect of stimulation on response initiation and inhibition. A total of 14 patients with severe Tourette syndrome were recruited and tested on the sto...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066761/ https://www.ncbi.nlm.nih.gov/pubmed/33916444 http://dx.doi.org/10.3390/brainsci11040461 |
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author | Morreale, Francesca Kefalopoulou, Zinovia Zrinzo, Ludvic Limousin, Patricia Joyce, Eileen Foltynie, Tom Jahanshahi, Marjan |
author_facet | Morreale, Francesca Kefalopoulou, Zinovia Zrinzo, Ludvic Limousin, Patricia Joyce, Eileen Foltynie, Tom Jahanshahi, Marjan |
author_sort | Morreale, Francesca |
collection | PubMed |
description | As part of the first randomized double-blind trial of deep brain stimulation (DBS) of the globus pallidus (GPi) in Tourette syndrome, we examined the effect of stimulation on response initiation and inhibition. A total of 14 patients with severe Tourette syndrome were recruited and tested on the stop signal task prior to and after GPi-DBS surgery and compared to eight age-matched healthy controls. Tics were significantly improved following GPi-DBS. The main measure of reactive inhibition, the stop signal reaction time did not change from before to after surgery and did not differ from that of healthy controls either before or after GPi-DBS surgery. This suggests that patients with Tourette syndrome have normal reactive inhibition which is not significantly altered by GPi-DBS. |
format | Online Article Text |
id | pubmed-8066761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80667612021-04-25 Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus Morreale, Francesca Kefalopoulou, Zinovia Zrinzo, Ludvic Limousin, Patricia Joyce, Eileen Foltynie, Tom Jahanshahi, Marjan Brain Sci Article As part of the first randomized double-blind trial of deep brain stimulation (DBS) of the globus pallidus (GPi) in Tourette syndrome, we examined the effect of stimulation on response initiation and inhibition. A total of 14 patients with severe Tourette syndrome were recruited and tested on the stop signal task prior to and after GPi-DBS surgery and compared to eight age-matched healthy controls. Tics were significantly improved following GPi-DBS. The main measure of reactive inhibition, the stop signal reaction time did not change from before to after surgery and did not differ from that of healthy controls either before or after GPi-DBS surgery. This suggests that patients with Tourette syndrome have normal reactive inhibition which is not significantly altered by GPi-DBS. MDPI 2021-04-05 /pmc/articles/PMC8066761/ /pubmed/33916444 http://dx.doi.org/10.3390/brainsci11040461 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Morreale, Francesca Kefalopoulou, Zinovia Zrinzo, Ludvic Limousin, Patricia Joyce, Eileen Foltynie, Tom Jahanshahi, Marjan Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus |
title | Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus |
title_full | Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus |
title_fullStr | Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus |
title_full_unstemmed | Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus |
title_short | Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus |
title_sort | inhibitory control on a stop signal task in tourette syndrome before and after deep brain stimulation of the internal segment of the globus pallidus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066761/ https://www.ncbi.nlm.nih.gov/pubmed/33916444 http://dx.doi.org/10.3390/brainsci11040461 |
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