Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome

Chloramphenicol (CHL) is a ribosome-targeting antibiotic that binds to the peptidyl transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As an approach for modifying and potentially improving the properties of this inhibitor, we explored ribosome binding and inhibi...

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Detalles Bibliográficos
Autores principales: Chen, Chih-Wei, Pavlova, Julia A., Lukianov, Dmitrii A., Tereshchenkov, Andrey G., Makarov, Gennady I., Khairullina, Zimfira Z., Tashlitsky, Vadim N., Paleskava, Alena, Konevega, Andrey L., Bogdanov, Alexey A., Osterman, Ilya A., Sumbatyan, Natalia V., Polikanov, Yury S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066774/
https://www.ncbi.nlm.nih.gov/pubmed/33916420
http://dx.doi.org/10.3390/antibiotics10040390

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