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Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications

Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the advan...

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Detalles Bibliográficos
Autores principales: Miranda, Bruno, Rea, Ilaria, Dardano, Principia, De Stefano, Luca, Forestiere, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066870/
https://www.ncbi.nlm.nih.gov/pubmed/33916580
http://dx.doi.org/10.3390/bios11040107
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author Miranda, Bruno
Rea, Ilaria
Dardano, Principia
De Stefano, Luca
Forestiere, Carlo
author_facet Miranda, Bruno
Rea, Ilaria
Dardano, Principia
De Stefano, Luca
Forestiere, Carlo
author_sort Miranda, Bruno
collection PubMed
description Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the advantage of adapting to non-planar surfaces, suitable for in vivo and real-time monitoring of diseases and assessment of food safety. In this review, we summarize the newest and most advanced platforms coupling optically active materials (noble metal nanoparticles) and flexible substrates giving rise to hybrid nanomaterials and/or nanocomposites, whose performances are comparable to the ones obtained with hard substrates (e.g., glass and semiconductors). We focus on localized surface plasmon resonance (LSPR)-based and surface-enhanced Raman spectroscopy (SERS)-based biosensors. We show that large-scale, cost-effective plasmonic platforms can be realized with the currently available techniques and we emphasize the open issues associated with this topic.
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spelling pubmed-80668702021-04-25 Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications Miranda, Bruno Rea, Ilaria Dardano, Principia De Stefano, Luca Forestiere, Carlo Biosensors (Basel) Review Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the advantage of adapting to non-planar surfaces, suitable for in vivo and real-time monitoring of diseases and assessment of food safety. In this review, we summarize the newest and most advanced platforms coupling optically active materials (noble metal nanoparticles) and flexible substrates giving rise to hybrid nanomaterials and/or nanocomposites, whose performances are comparable to the ones obtained with hard substrates (e.g., glass and semiconductors). We focus on localized surface plasmon resonance (LSPR)-based and surface-enhanced Raman spectroscopy (SERS)-based biosensors. We show that large-scale, cost-effective plasmonic platforms can be realized with the currently available techniques and we emphasize the open issues associated with this topic. MDPI 2021-04-04 /pmc/articles/PMC8066870/ /pubmed/33916580 http://dx.doi.org/10.3390/bios11040107 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miranda, Bruno
Rea, Ilaria
Dardano, Principia
De Stefano, Luca
Forestiere, Carlo
Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
title Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
title_full Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
title_fullStr Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
title_full_unstemmed Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
title_short Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
title_sort recent advances in the fabrication and functionalization of flexible optical biosensors: toward smart life-sciences applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066870/
https://www.ncbi.nlm.nih.gov/pubmed/33916580
http://dx.doi.org/10.3390/bios11040107
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