Cargando…

Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil

BACKGROUND: Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections are the most common sexually transmitted infections (STIs) globally. The latter has contributed to a variety of adverse outcomes for both sexes. Moreover, in Brazil, epidemiological studies on patients with STIs are lim...

Descripción completa

Detalles Bibliográficos
Autores principales: Belfort, Ilka Kassandra Pereira, Cunha, Ana Paula Almeida, Mendes, Francisco Pedro Belfort, Galvão-Moreira, Leonardo Victor, Lemos, Renata Gaspar, de Lima Costa, Lucas Henrique, Monteiro, Pablo, Ferreira, Mariele Borges, dos Santos, Gerusinete Rodrigues Bastos, Costa, Joyce Leal, de Sá Ferreira, Alice, Brito, Luiz Gustavo Oliveira, Brito, Luciane Maria Oliveira, Vidal, Flávia Castello Branco, Monteiro, Sally Cristina Moutinho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066958/
https://www.ncbi.nlm.nih.gov/pubmed/33892709
http://dx.doi.org/10.1186/s12905-021-01320-6
_version_ 1783682689517223936
author Belfort, Ilka Kassandra Pereira
Cunha, Ana Paula Almeida
Mendes, Francisco Pedro Belfort
Galvão-Moreira, Leonardo Victor
Lemos, Renata Gaspar
de Lima Costa, Lucas Henrique
Monteiro, Pablo
Ferreira, Mariele Borges
dos Santos, Gerusinete Rodrigues Bastos
Costa, Joyce Leal
de Sá Ferreira, Alice
Brito, Luiz Gustavo Oliveira
Brito, Luciane Maria Oliveira
Vidal, Flávia Castello Branco
Monteiro, Sally Cristina Moutinho
author_facet Belfort, Ilka Kassandra Pereira
Cunha, Ana Paula Almeida
Mendes, Francisco Pedro Belfort
Galvão-Moreira, Leonardo Victor
Lemos, Renata Gaspar
de Lima Costa, Lucas Henrique
Monteiro, Pablo
Ferreira, Mariele Borges
dos Santos, Gerusinete Rodrigues Bastos
Costa, Joyce Leal
de Sá Ferreira, Alice
Brito, Luiz Gustavo Oliveira
Brito, Luciane Maria Oliveira
Vidal, Flávia Castello Branco
Monteiro, Sally Cristina Moutinho
author_sort Belfort, Ilka Kassandra Pereira
collection PubMed
description BACKGROUND: Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections are the most common sexually transmitted infections (STIs) globally. The latter has contributed to a variety of adverse outcomes for both sexes. Moreover, in Brazil, epidemiological studies on patients with STIs are limited. Therefore, this study aimed to determine the prevalence of TV and its association with HPV in women undergoing cervical cancer screening. METHODS: Women with a normal cervix were recruited from a community-based cervical cancer screening program. Gynecological examinations were conducted, and questionnaires were provided. Vaginal canal and uterine cervix samples were collected for cytological examinations (reported using the 2001 Bethesda System) and tested for the presence of TV and HPV DNA. RESULTS: In total, 562 women who attended public primary healthcare were included in the study. The T. vaginalis was present in 19.0% (107) and HPV DNA was present in 46.8% (263) of women. Among the women of TV 73.8% (79) had a co-infection with HPV (p = 0.001). CONCLUSIONS: We concluded that a TV infection is associated with an HPV infection of the cervix as well as with the cervical cytological abnormalities. Further studies could reveal the mechanisms by which these two organisms interact at the cellular level, with control for shared behavioral risk factors.
format Online
Article
Text
id pubmed-8066958
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-80669582021-04-26 Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil Belfort, Ilka Kassandra Pereira Cunha, Ana Paula Almeida Mendes, Francisco Pedro Belfort Galvão-Moreira, Leonardo Victor Lemos, Renata Gaspar de Lima Costa, Lucas Henrique Monteiro, Pablo Ferreira, Mariele Borges dos Santos, Gerusinete Rodrigues Bastos Costa, Joyce Leal de Sá Ferreira, Alice Brito, Luiz Gustavo Oliveira Brito, Luciane Maria Oliveira Vidal, Flávia Castello Branco Monteiro, Sally Cristina Moutinho BMC Womens Health Research Article BACKGROUND: Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections are the most common sexually transmitted infections (STIs) globally. The latter has contributed to a variety of adverse outcomes for both sexes. Moreover, in Brazil, epidemiological studies on patients with STIs are limited. Therefore, this study aimed to determine the prevalence of TV and its association with HPV in women undergoing cervical cancer screening. METHODS: Women with a normal cervix were recruited from a community-based cervical cancer screening program. Gynecological examinations were conducted, and questionnaires were provided. Vaginal canal and uterine cervix samples were collected for cytological examinations (reported using the 2001 Bethesda System) and tested for the presence of TV and HPV DNA. RESULTS: In total, 562 women who attended public primary healthcare were included in the study. The T. vaginalis was present in 19.0% (107) and HPV DNA was present in 46.8% (263) of women. Among the women of TV 73.8% (79) had a co-infection with HPV (p = 0.001). CONCLUSIONS: We concluded that a TV infection is associated with an HPV infection of the cervix as well as with the cervical cytological abnormalities. Further studies could reveal the mechanisms by which these two organisms interact at the cellular level, with control for shared behavioral risk factors. BioMed Central 2021-04-23 /pmc/articles/PMC8066958/ /pubmed/33892709 http://dx.doi.org/10.1186/s12905-021-01320-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Belfort, Ilka Kassandra Pereira
Cunha, Ana Paula Almeida
Mendes, Francisco Pedro Belfort
Galvão-Moreira, Leonardo Victor
Lemos, Renata Gaspar
de Lima Costa, Lucas Henrique
Monteiro, Pablo
Ferreira, Mariele Borges
dos Santos, Gerusinete Rodrigues Bastos
Costa, Joyce Leal
de Sá Ferreira, Alice
Brito, Luiz Gustavo Oliveira
Brito, Luciane Maria Oliveira
Vidal, Flávia Castello Branco
Monteiro, Sally Cristina Moutinho
Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil
title Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil
title_full Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil
title_fullStr Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil
title_full_unstemmed Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil
title_short Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil
title_sort trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066958/
https://www.ncbi.nlm.nih.gov/pubmed/33892709
http://dx.doi.org/10.1186/s12905-021-01320-6
work_keys_str_mv AT belfortilkakassandrapereira trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT cunhaanapaulaalmeida trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT mendesfranciscopedrobelfort trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT galvaomoreiraleonardovictor trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT lemosrenatagaspar trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT delimacostalucashenrique trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT monteiropablo trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT ferreiramarieleborges trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT dossantosgerusineterodriguesbastos trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT costajoyceleal trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT desaferreiraalice trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT britoluizgustavooliveira trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT britolucianemariaoliveira trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT vidalflaviacastellobranco trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil
AT monteirosallycristinamoutinho trichomonasvaginalisasariskfactorforhumanpapillomavirusastudywithwomenundergoingcervicalcancerscreeninginanortheastregionofbrazil