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Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece

Group B streptococcus (GBS) is a leading cause of serious neonatal infections. Maternal GBS colonization is associated with early- and late-onset neonatal disease (EOD/LOD). In Greece, a screening-based strategy is recommended, in which concurrent vaginal-rectal cultures should be obtained between 3...

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Autores principales: Berikopoulou, Maria Maroudia, Pana, Aikaterini, Liakopoulou-Tsitsipi, Theodota, Vlahos, Nikos F., Papaevangelou, Vasiliki, Soldatou, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067163/
https://www.ncbi.nlm.nih.gov/pubmed/33915970
http://dx.doi.org/10.3390/pathogens10040418
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author Berikopoulou, Maria Maroudia
Pana, Aikaterini
Liakopoulou-Tsitsipi, Theodota
Vlahos, Nikos F.
Papaevangelou, Vasiliki
Soldatou, Alexandra
author_facet Berikopoulou, Maria Maroudia
Pana, Aikaterini
Liakopoulou-Tsitsipi, Theodota
Vlahos, Nikos F.
Papaevangelou, Vasiliki
Soldatou, Alexandra
author_sort Berikopoulou, Maria Maroudia
collection PubMed
description Group B streptococcus (GBS) is a leading cause of serious neonatal infections. Maternal GBS colonization is associated with early- and late-onset neonatal disease (EOD/LOD). In Greece, a screening-based strategy is recommended, in which concurrent vaginal-rectal cultures should be obtained between 36 0/7 and 37 6/7 weeks’ gestation. We sought to examine the level of adherence to the GBS screening guidelines and estimate the prevalence of GBS colonization among pregnant women. Although in Greece the screening-based strategy is followed, we also examined known EOD risk factors and linked them to GBS colonization. A cross-sectional study of 604 women postpartum in three hospitals and maternity clinics was conducted. Following written informed consent, data were collected via a short self-completed questionnaire and review of patients’ records. In 34.6% of the enrolled pregnant women, no culture had been taken. Of the remaining, 12.8% had proper vaginal-rectal sample collections. The overall maternal colonization rate was 9.6%. At least one risk factor for EOD was identified in 12.6% of participants. The presence of risk factors was associated with positive cultures (p = 0.014). The rate of culture collection did not differ between women with or without an EOD risk factor. Adherence to a universal screening of pregnant women with vaginal-rectal cultures was poor. Despite probable underestimation of GBS carrier status, almost 1 in 10 participants were GBS positive during pregnancy. Screening of women with risk factors for EOD should, at least, be prioritized to achieve prevention and prompt intervention of EOD.
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spelling pubmed-80671632021-04-25 Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece Berikopoulou, Maria Maroudia Pana, Aikaterini Liakopoulou-Tsitsipi, Theodota Vlahos, Nikos F. Papaevangelou, Vasiliki Soldatou, Alexandra Pathogens Article Group B streptococcus (GBS) is a leading cause of serious neonatal infections. Maternal GBS colonization is associated with early- and late-onset neonatal disease (EOD/LOD). In Greece, a screening-based strategy is recommended, in which concurrent vaginal-rectal cultures should be obtained between 36 0/7 and 37 6/7 weeks’ gestation. We sought to examine the level of adherence to the GBS screening guidelines and estimate the prevalence of GBS colonization among pregnant women. Although in Greece the screening-based strategy is followed, we also examined known EOD risk factors and linked them to GBS colonization. A cross-sectional study of 604 women postpartum in three hospitals and maternity clinics was conducted. Following written informed consent, data were collected via a short self-completed questionnaire and review of patients’ records. In 34.6% of the enrolled pregnant women, no culture had been taken. Of the remaining, 12.8% had proper vaginal-rectal sample collections. The overall maternal colonization rate was 9.6%. At least one risk factor for EOD was identified in 12.6% of participants. The presence of risk factors was associated with positive cultures (p = 0.014). The rate of culture collection did not differ between women with or without an EOD risk factor. Adherence to a universal screening of pregnant women with vaginal-rectal cultures was poor. Despite probable underestimation of GBS carrier status, almost 1 in 10 participants were GBS positive during pregnancy. Screening of women with risk factors for EOD should, at least, be prioritized to achieve prevention and prompt intervention of EOD. MDPI 2021-04-01 /pmc/articles/PMC8067163/ /pubmed/33915970 http://dx.doi.org/10.3390/pathogens10040418 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Berikopoulou, Maria Maroudia
Pana, Aikaterini
Liakopoulou-Tsitsipi, Theodota
Vlahos, Nikos F.
Papaevangelou, Vasiliki
Soldatou, Alexandra
Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece
title Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece
title_full Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece
title_fullStr Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece
title_full_unstemmed Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece
title_short Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece
title_sort poor adherence to the screening-based strategy of group b streptococcus despite colonization of pregnant women in greece
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067163/
https://www.ncbi.nlm.nih.gov/pubmed/33915970
http://dx.doi.org/10.3390/pathogens10040418
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