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Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus

The burden of hepatitis B virus (HBV) infection is a serious public health problem all over the world. Vaccination remains the most effective prevention measure, and safe and effective HBV vaccines have been available since 1982. Health care workers (HCWs) vaccinated against HBV and prospectively fo...

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Autores principales: Cocchio, Silvia, Baldo, Vincenzo, Volpin, Anna, Fonzo, Marco, Floreani, Annarosa, Furlan, Patrizia, Mason, Paola, Trevisan, Andrea, Scapellato, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067181/
https://www.ncbi.nlm.nih.gov/pubmed/33915763
http://dx.doi.org/10.3390/vaccines9040323
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author Cocchio, Silvia
Baldo, Vincenzo
Volpin, Anna
Fonzo, Marco
Floreani, Annarosa
Furlan, Patrizia
Mason, Paola
Trevisan, Andrea
Scapellato, Maria Luisa
author_facet Cocchio, Silvia
Baldo, Vincenzo
Volpin, Anna
Fonzo, Marco
Floreani, Annarosa
Furlan, Patrizia
Mason, Paola
Trevisan, Andrea
Scapellato, Maria Luisa
author_sort Cocchio, Silvia
collection PubMed
description The burden of hepatitis B virus (HBV) infection is a serious public health problem all over the world. Vaccination remains the most effective prevention measure, and safe and effective HBV vaccines have been available since 1982. Health care workers (HCWs) vaccinated against HBV and prospectively followed up for at least 14 years were classified by their antibody titers after primary vaccination as: poor responders (10–99 mIU/mL); moderate responders (100–999 mIU/mL); and good responders (≥1000 mIU/mL). The incidence of antibody loss was calculated for 1000 person-years and the anti-HBs persistence was calculated. The analysis concerned 539 HCWs: 494 good responders (91.7%); 37 moderate responders (6.9%); and eight poor responders (1.5%). The incidence of anti-HBs loss was 52.1 per 1000 person-years for the poor responders, 11.3 per 1000 person-years for the moderate responders, and 1.4 per 1000 person-years for the good responders. The mean persistence of anti-HBs differed significantly between the three groups, being: 19.2 years (95% CI: 15.6–22.8), 25.4 years (95% CI: 23.0–27.9), and 31.0 years (95% CI: 30.5–31.5) for the poor, moderate and good responders, respectively. In conclusion, our findings demonstrate a good persistence of protective anti-HBs titers in HCWs exposed to occupational risk for up to 30 years after a primary vaccination cycle (even without a booster dose) if their titer was initially higher than 100 mIU/mL.
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spelling pubmed-80671812021-04-25 Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus Cocchio, Silvia Baldo, Vincenzo Volpin, Anna Fonzo, Marco Floreani, Annarosa Furlan, Patrizia Mason, Paola Trevisan, Andrea Scapellato, Maria Luisa Vaccines (Basel) Article The burden of hepatitis B virus (HBV) infection is a serious public health problem all over the world. Vaccination remains the most effective prevention measure, and safe and effective HBV vaccines have been available since 1982. Health care workers (HCWs) vaccinated against HBV and prospectively followed up for at least 14 years were classified by their antibody titers after primary vaccination as: poor responders (10–99 mIU/mL); moderate responders (100–999 mIU/mL); and good responders (≥1000 mIU/mL). The incidence of antibody loss was calculated for 1000 person-years and the anti-HBs persistence was calculated. The analysis concerned 539 HCWs: 494 good responders (91.7%); 37 moderate responders (6.9%); and eight poor responders (1.5%). The incidence of anti-HBs loss was 52.1 per 1000 person-years for the poor responders, 11.3 per 1000 person-years for the moderate responders, and 1.4 per 1000 person-years for the good responders. The mean persistence of anti-HBs differed significantly between the three groups, being: 19.2 years (95% CI: 15.6–22.8), 25.4 years (95% CI: 23.0–27.9), and 31.0 years (95% CI: 30.5–31.5) for the poor, moderate and good responders, respectively. In conclusion, our findings demonstrate a good persistence of protective anti-HBs titers in HCWs exposed to occupational risk for up to 30 years after a primary vaccination cycle (even without a booster dose) if their titer was initially higher than 100 mIU/mL. MDPI 2021-04-01 /pmc/articles/PMC8067181/ /pubmed/33915763 http://dx.doi.org/10.3390/vaccines9040323 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cocchio, Silvia
Baldo, Vincenzo
Volpin, Anna
Fonzo, Marco
Floreani, Annarosa
Furlan, Patrizia
Mason, Paola
Trevisan, Andrea
Scapellato, Maria Luisa
Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus
title Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus
title_full Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus
title_fullStr Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus
title_full_unstemmed Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus
title_short Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus
title_sort persistence of anti-hbs after up to 30 years in health care workers vaccinated against hepatitis b virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067181/
https://www.ncbi.nlm.nih.gov/pubmed/33915763
http://dx.doi.org/10.3390/vaccines9040323
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