Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin

Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular...

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Autores principales: Focosi, Daniele, Genoni, Angelo, Lucenteforte, Ersilia, Tillati, Silvia, Tamborini, Antonio, Spezia, Pietro Giorgio, Azzi, Lorenzo, Baj, Andreina, Maggi, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067214/
https://www.ncbi.nlm.nih.gov/pubmed/33915711
http://dx.doi.org/10.3390/life11040298
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author Focosi, Daniele
Genoni, Angelo
Lucenteforte, Ersilia
Tillati, Silvia
Tamborini, Antonio
Spezia, Pietro Giorgio
Azzi, Lorenzo
Baj, Andreina
Maggi, Fabrizio
author_facet Focosi, Daniele
Genoni, Angelo
Lucenteforte, Ersilia
Tillati, Silvia
Tamborini, Antonio
Spezia, Pietro Giorgio
Azzi, Lorenzo
Baj, Andreina
Maggi, Fabrizio
author_sort Focosi, Daniele
collection PubMed
description Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular and humoral immunity. We show here that IgG against nucleocapsid protein of alphacoronavirus NL63 and 229E correlate with the World Health Organization’s (WHO) clinical severity score ≥ 5 (incidence rate ratios was 1.87 and 1.80, respectively, and 1.94 for the combination). These laboratory findings suggest possible ADE of SARS CoV-2 infection by previous alphacoronavirus immunity.
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spelling pubmed-80672142021-04-25 Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin Focosi, Daniele Genoni, Angelo Lucenteforte, Ersilia Tillati, Silvia Tamborini, Antonio Spezia, Pietro Giorgio Azzi, Lorenzo Baj, Andreina Maggi, Fabrizio Life (Basel) Article Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular and humoral immunity. We show here that IgG against nucleocapsid protein of alphacoronavirus NL63 and 229E correlate with the World Health Organization’s (WHO) clinical severity score ≥ 5 (incidence rate ratios was 1.87 and 1.80, respectively, and 1.94 for the combination). These laboratory findings suggest possible ADE of SARS CoV-2 infection by previous alphacoronavirus immunity. MDPI 2021-04-01 /pmc/articles/PMC8067214/ /pubmed/33915711 http://dx.doi.org/10.3390/life11040298 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Focosi, Daniele
Genoni, Angelo
Lucenteforte, Ersilia
Tillati, Silvia
Tamborini, Antonio
Spezia, Pietro Giorgio
Azzi, Lorenzo
Baj, Andreina
Maggi, Fabrizio
Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
title Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
title_full Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
title_fullStr Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
title_full_unstemmed Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
title_short Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
title_sort previous humoral immunity to the endemic seasonal alphacoronaviruses nl63 and 229e is associated with worse clinical outcome in covid-19 and suggests original antigenic sin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067214/
https://www.ncbi.nlm.nih.gov/pubmed/33915711
http://dx.doi.org/10.3390/life11040298
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