Cargando…

Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study

Childhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, ver...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Danielle, De Lucia Rolfe, Emanuella, Rennie, Kirsten L., Griep, Linda M. Oude, Kusinski, Laura C., Hughes, Deborah J., Brage, Soren, Ong, Ken K., Beardsall, Kathryn, Meek, Claire L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067255/
https://www.ncbi.nlm.nih.gov/pubmed/33807319
http://dx.doi.org/10.3390/nu13041156
_version_ 1783682760335949824
author Jones, Danielle
De Lucia Rolfe, Emanuella
Rennie, Kirsten L.
Griep, Linda M. Oude
Kusinski, Laura C.
Hughes, Deborah J.
Brage, Soren
Ong, Ken K.
Beardsall, Kathryn
Meek, Claire L.
author_facet Jones, Danielle
De Lucia Rolfe, Emanuella
Rennie, Kirsten L.
Griep, Linda M. Oude
Kusinski, Laura C.
Hughes, Deborah J.
Brage, Soren
Ong, Ken K.
Beardsall, Kathryn
Meek, Claire L.
author_sort Jones, Danielle
collection PubMed
description Childhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, very few successful interventions in pregnancy have been identified. We describe a study protocol to identify if a reduced calorie diet in pregnancy can reduce adiposity in children to 3 years of age. The dietary intervention in gestational diabetes (DiGest) study is a randomised, controlled trial of a reduced calorie diet provided by a whole-diet replacement in pregnant women with gestational diabetes. Women receive a weekly dietbox intervention from enrolment until delivery and are blinded to calorie allocation. This follow-up study will assess associations between a reduced calorie diet in pregnancy with offspring adiposity and maternal weight and glycaemia. Anthropometry will be performed in infants and mothers at 3 months, 1, 2 and 3 years post-birth. Glycaemia will be assessed using bloodspot C-peptide in infants and continuous glucose monitoring with HbA1c in mothers. Data regarding maternal glycaemia in pregnancy, maternal nutrition, infant birthweight, offspring feeding behaviour and milk composition will also be collected. The DiGest follow-up study is expected to take 5 years, with recruitment finishing in 2026.
format Online
Article
Text
id pubmed-8067255
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80672552021-04-25 Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study Jones, Danielle De Lucia Rolfe, Emanuella Rennie, Kirsten L. Griep, Linda M. Oude Kusinski, Laura C. Hughes, Deborah J. Brage, Soren Ong, Ken K. Beardsall, Kathryn Meek, Claire L. Nutrients Article Childhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, very few successful interventions in pregnancy have been identified. We describe a study protocol to identify if a reduced calorie diet in pregnancy can reduce adiposity in children to 3 years of age. The dietary intervention in gestational diabetes (DiGest) study is a randomised, controlled trial of a reduced calorie diet provided by a whole-diet replacement in pregnant women with gestational diabetes. Women receive a weekly dietbox intervention from enrolment until delivery and are blinded to calorie allocation. This follow-up study will assess associations between a reduced calorie diet in pregnancy with offspring adiposity and maternal weight and glycaemia. Anthropometry will be performed in infants and mothers at 3 months, 1, 2 and 3 years post-birth. Glycaemia will be assessed using bloodspot C-peptide in infants and continuous glucose monitoring with HbA1c in mothers. Data regarding maternal glycaemia in pregnancy, maternal nutrition, infant birthweight, offspring feeding behaviour and milk composition will also be collected. The DiGest follow-up study is expected to take 5 years, with recruitment finishing in 2026. MDPI 2021-03-31 /pmc/articles/PMC8067255/ /pubmed/33807319 http://dx.doi.org/10.3390/nu13041156 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jones, Danielle
De Lucia Rolfe, Emanuella
Rennie, Kirsten L.
Griep, Linda M. Oude
Kusinski, Laura C.
Hughes, Deborah J.
Brage, Soren
Ong, Ken K.
Beardsall, Kathryn
Meek, Claire L.
Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study
title Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study
title_full Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study
title_fullStr Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study
title_full_unstemmed Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study
title_short Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study
title_sort antenatal determinants of childhood obesity in high-risk offspring: protocol for the digest follow-up study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067255/
https://www.ncbi.nlm.nih.gov/pubmed/33807319
http://dx.doi.org/10.3390/nu13041156
work_keys_str_mv AT jonesdanielle antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT deluciarolfeemanuella antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT renniekirstenl antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT grieplindamoude antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT kusinskilaurac antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT hughesdeborahj antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT bragesoren antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT ongkenk antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT beardsallkathryn antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy
AT meekclairel antenataldeterminantsofchildhoodobesityinhighriskoffspringprotocolforthedigestfollowupstudy