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Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues
Percutaneously implanted miniaturized devices such as fiducial markers, miniaturized sensors, and drug delivery devices have an important and expanding role in diagnosing and treating a variety of diseases. However, there is a need to develop and evaluate anchoring methods to ensure that these micro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067345/ https://www.ncbi.nlm.nih.gov/pubmed/33917289 http://dx.doi.org/10.3390/mi12040404 |
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author | Bhagavatula, Sharath Thompson, Devon Dominas, Christine Haider, Irfanullah Jonas, Oliver |
author_facet | Bhagavatula, Sharath Thompson, Devon Dominas, Christine Haider, Irfanullah Jonas, Oliver |
author_sort | Bhagavatula, Sharath |
collection | PubMed |
description | Percutaneously implanted miniaturized devices such as fiducial markers, miniaturized sensors, and drug delivery devices have an important and expanding role in diagnosing and treating a variety of diseases. However, there is a need to develop and evaluate anchoring methods to ensure that these microdevices remain secure without dislodgement, as even minimal migration within tissues could result in loss of microdevice functionality or clinical complications. Here we describe two anchoring methods made from biocompatible materials: (1) a self-expanding nitinol mesh anchor and (2) self-expanding hydrogel particles contained within pliable netting. We integrate these anchors into existing drug-screening microdevices and experimentally measure forces required to dislodge them from varying tissues. We report similar dislodgement forces of 738 ± 37, 707 ± 40, 688 ± 29, and 520 ± 28 mN for nitinol-anchored microdevices, and 735 ± 98, 702 ± 46, 457 ± 47, and 459 ± 39 mN for hydrogel-anchored microdevices in liver, kidney, fat, and muscle tissues, respectively—significantly higher compared with 13 ± 2, 15 ± 3, 15 ± 2, and 15 ± 3 mN for non-anchored microdevices (p < 0.001 in all tissues). The anchoring methods increased resistance to dislodgement by a factor of 30–50× in all tissues, did not increase the required needle gauge for insertion, and were compatible with percutaneous implantation and removal. These results indicate that anchoring significantly improves microdevice stability and should reduce migration risk in a variety of biological tissues. |
format | Online Article Text |
id | pubmed-8067345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80673452021-04-25 Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues Bhagavatula, Sharath Thompson, Devon Dominas, Christine Haider, Irfanullah Jonas, Oliver Micromachines (Basel) Article Percutaneously implanted miniaturized devices such as fiducial markers, miniaturized sensors, and drug delivery devices have an important and expanding role in diagnosing and treating a variety of diseases. However, there is a need to develop and evaluate anchoring methods to ensure that these microdevices remain secure without dislodgement, as even minimal migration within tissues could result in loss of microdevice functionality or clinical complications. Here we describe two anchoring methods made from biocompatible materials: (1) a self-expanding nitinol mesh anchor and (2) self-expanding hydrogel particles contained within pliable netting. We integrate these anchors into existing drug-screening microdevices and experimentally measure forces required to dislodge them from varying tissues. We report similar dislodgement forces of 738 ± 37, 707 ± 40, 688 ± 29, and 520 ± 28 mN for nitinol-anchored microdevices, and 735 ± 98, 702 ± 46, 457 ± 47, and 459 ± 39 mN for hydrogel-anchored microdevices in liver, kidney, fat, and muscle tissues, respectively—significantly higher compared with 13 ± 2, 15 ± 3, 15 ± 2, and 15 ± 3 mN for non-anchored microdevices (p < 0.001 in all tissues). The anchoring methods increased resistance to dislodgement by a factor of 30–50× in all tissues, did not increase the required needle gauge for insertion, and were compatible with percutaneous implantation and removal. These results indicate that anchoring significantly improves microdevice stability and should reduce migration risk in a variety of biological tissues. MDPI 2021-04-06 /pmc/articles/PMC8067345/ /pubmed/33917289 http://dx.doi.org/10.3390/mi12040404 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bhagavatula, Sharath Thompson, Devon Dominas, Christine Haider, Irfanullah Jonas, Oliver Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues |
title | Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues |
title_full | Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues |
title_fullStr | Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues |
title_full_unstemmed | Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues |
title_short | Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues |
title_sort | self-expanding anchors for stabilizing percutaneously implanted microdevices in biological tissues |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067345/ https://www.ncbi.nlm.nih.gov/pubmed/33917289 http://dx.doi.org/10.3390/mi12040404 |
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