Cargando…

Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues

Percutaneously implanted miniaturized devices such as fiducial markers, miniaturized sensors, and drug delivery devices have an important and expanding role in diagnosing and treating a variety of diseases. However, there is a need to develop and evaluate anchoring methods to ensure that these micro...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhagavatula, Sharath, Thompson, Devon, Dominas, Christine, Haider, Irfanullah, Jonas, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067345/
https://www.ncbi.nlm.nih.gov/pubmed/33917289
http://dx.doi.org/10.3390/mi12040404
_version_ 1783682781346267136
author Bhagavatula, Sharath
Thompson, Devon
Dominas, Christine
Haider, Irfanullah
Jonas, Oliver
author_facet Bhagavatula, Sharath
Thompson, Devon
Dominas, Christine
Haider, Irfanullah
Jonas, Oliver
author_sort Bhagavatula, Sharath
collection PubMed
description Percutaneously implanted miniaturized devices such as fiducial markers, miniaturized sensors, and drug delivery devices have an important and expanding role in diagnosing and treating a variety of diseases. However, there is a need to develop and evaluate anchoring methods to ensure that these microdevices remain secure without dislodgement, as even minimal migration within tissues could result in loss of microdevice functionality or clinical complications. Here we describe two anchoring methods made from biocompatible materials: (1) a self-expanding nitinol mesh anchor and (2) self-expanding hydrogel particles contained within pliable netting. We integrate these anchors into existing drug-screening microdevices and experimentally measure forces required to dislodge them from varying tissues. We report similar dislodgement forces of 738 ± 37, 707 ± 40, 688 ± 29, and 520 ± 28 mN for nitinol-anchored microdevices, and 735 ± 98, 702 ± 46, 457 ± 47, and 459 ± 39 mN for hydrogel-anchored microdevices in liver, kidney, fat, and muscle tissues, respectively—significantly higher compared with 13 ± 2, 15 ± 3, 15 ± 2, and 15 ± 3 mN for non-anchored microdevices (p < 0.001 in all tissues). The anchoring methods increased resistance to dislodgement by a factor of 30–50× in all tissues, did not increase the required needle gauge for insertion, and were compatible with percutaneous implantation and removal. These results indicate that anchoring significantly improves microdevice stability and should reduce migration risk in a variety of biological tissues.
format Online
Article
Text
id pubmed-8067345
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80673452021-04-25 Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues Bhagavatula, Sharath Thompson, Devon Dominas, Christine Haider, Irfanullah Jonas, Oliver Micromachines (Basel) Article Percutaneously implanted miniaturized devices such as fiducial markers, miniaturized sensors, and drug delivery devices have an important and expanding role in diagnosing and treating a variety of diseases. However, there is a need to develop and evaluate anchoring methods to ensure that these microdevices remain secure without dislodgement, as even minimal migration within tissues could result in loss of microdevice functionality or clinical complications. Here we describe two anchoring methods made from biocompatible materials: (1) a self-expanding nitinol mesh anchor and (2) self-expanding hydrogel particles contained within pliable netting. We integrate these anchors into existing drug-screening microdevices and experimentally measure forces required to dislodge them from varying tissues. We report similar dislodgement forces of 738 ± 37, 707 ± 40, 688 ± 29, and 520 ± 28 mN for nitinol-anchored microdevices, and 735 ± 98, 702 ± 46, 457 ± 47, and 459 ± 39 mN for hydrogel-anchored microdevices in liver, kidney, fat, and muscle tissues, respectively—significantly higher compared with 13 ± 2, 15 ± 3, 15 ± 2, and 15 ± 3 mN for non-anchored microdevices (p < 0.001 in all tissues). The anchoring methods increased resistance to dislodgement by a factor of 30–50× in all tissues, did not increase the required needle gauge for insertion, and were compatible with percutaneous implantation and removal. These results indicate that anchoring significantly improves microdevice stability and should reduce migration risk in a variety of biological tissues. MDPI 2021-04-06 /pmc/articles/PMC8067345/ /pubmed/33917289 http://dx.doi.org/10.3390/mi12040404 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bhagavatula, Sharath
Thompson, Devon
Dominas, Christine
Haider, Irfanullah
Jonas, Oliver
Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues
title Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues
title_full Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues
title_fullStr Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues
title_full_unstemmed Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues
title_short Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues
title_sort self-expanding anchors for stabilizing percutaneously implanted microdevices in biological tissues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067345/
https://www.ncbi.nlm.nih.gov/pubmed/33917289
http://dx.doi.org/10.3390/mi12040404
work_keys_str_mv AT bhagavatulasharath selfexpandinganchorsforstabilizingpercutaneouslyimplantedmicrodevicesinbiologicaltissues
AT thompsondevon selfexpandinganchorsforstabilizingpercutaneouslyimplantedmicrodevicesinbiologicaltissues
AT dominaschristine selfexpandinganchorsforstabilizingpercutaneouslyimplantedmicrodevicesinbiologicaltissues
AT haiderirfanullah selfexpandinganchorsforstabilizingpercutaneouslyimplantedmicrodevicesinbiologicaltissues
AT jonasoliver selfexpandinganchorsforstabilizingpercutaneouslyimplantedmicrodevicesinbiologicaltissues