Cargando…

Combined Ubisol-Q(10) and Ashwagandha Root Extract Target Multiple Biochemical Mechanisms and Reduces Neurodegeneration in a Paraquat-Induced Rat Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by progressive neurodegeneration in the substantia nigra (SN) region resulting in loss of movement coordination. Current therapies only provide symptomatic relief, and there is no agent to halt the progression of PD. Previously, Ubisol-Q(10), a water-soluble...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vegh, Caleb, Wear, Darcy, Okaj, Iva, Huggard, Rachel, Culmone, Lauren, Eren, Sezen, Cohen, Jerome, Rishi, Arun K., Pandey, Siyaram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067369/ https://www.ncbi.nlm.nih.gov/pubmed/33917328 http://dx.doi.org/10.3390/antiox10040563

Ejemplares similares

Resumption of Autophagy by Ubisol-Q(10) in Presenilin-1 Mutated Fibroblasts and Transgenic AD Mice: Implications for Inhibition of Senescence and Neuroprotection
por: Vegh, Caleb, et al.
Publicado: (2019)

Ubisol-Q(10), a Nanomicellar and Water-Dispersible Formulation of Coenzyme-Q(10) as a Potential Treatment for Alzheimer’s and Parkinson’s Disease
por: Wear, Darcy, et al.
Publicado: (2021)

Orally delivered water soluble Coenzyme Q(10) (Ubisol-Q(10)) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease
por: Muthukumaran, Krithika, et al.
Publicado: (2014)

Correction to: Orally delivered water soluble coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease
por: Muthukumaran, Krithika, et al.
Publicado: (2021)

Autophagy Inhibition via Hydroxychloroquine or 3-Methyladenine Enhances Chemotherapy-Induced Apoptosis in Neuro-Blastoma and Glioblastoma
por: Wear, Darcy, et al.
Publicado: (2023)

A Bird’s-Eye View of the Multiple Biochemical Mechanisms that Propel Pathology of Alzheimer’s Disease: Recent Advances and Mechanistic Perspectives on How to Halt the Disease Progression Targeting Multiple Pathways
por: Vegh, Caleb, et al.
Publicado: (2019)

Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate
por: Zimmerman, Mary A., et al.
Publicado: (2021)

Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening
por: Kumari, Santosh, et al.
Publicado: (2016)

VALIDATION OF ASHWAGANDHA CHURNAM
por: Nagavalli, D., et al.
Publicado: (2001)

A clinical study of Ashwagandha ghrita and Ashwagandha granules for its Brumhana and Balya effect
por: Mishra, Rakesh Kumar, et al.
Publicado: (2010)

Ashwagandha and Kidney Transplant Rejection
por: Sriperumbuduri, Sriram, et al.
Publicado: (2020)

Paraquat induces oxidative stress, neuronal loss in substantia nigra region and Parkinsonism in adult rats: Neuroprotection and amelioration of symptoms by water-soluble formulation of Coenzyme Q(10)
por: Somayajulu-Niţu, Mallika, et al.
Publicado: (2009)

Genetic Dissection of Strain Dependent Paraquat-induced Neurodegeneration in the Substantia Nigra Pars Compacta
por: Jiao, Yun, et al.
Publicado: (2012)

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation
por: Wang, Jia, et al.
Publicado: (2021)

Effects of Acute Ashwagandha Ingestion on Cognitive Function
por: Xing, Dante, et al.
Publicado: (2022)

Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects
por: Ruvinov, Ivan, et al.
Publicado: (2019)

Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root
por: Powell, Daniel, et al.
Publicado: (2017)

Can Ashwagandha Benefit the Endocrine System?—A Review
por: Wiciński, Michał, et al.
Publicado: (2023)

Acute aortic intraluminal thrombus with embolisation and lower-limb ischaemia following intravenous iron sucrose infusion reaction
por: Okaj, Iva, et al.
Publicado: (2023)

Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics
por: Nguyen, Christopher, et al.
Publicado: (2019)

Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer
por: Nguyen, Christopher, et al.
Publicado: (2019)

Comparison of Biochemical Parameters between Mouse Model and Human after Paraquat Poisoning
por: Yu, Jielun, et al.
Publicado: (2022)

Genotoxic, biochemical and histological biomarkers of subacute concentrations of paraquat and glyphosate in Nile Tilapia
por: Aribisala, Oluwatosin Aderinola, et al.
Publicado: (2022)

Effects of Withania somnifera (Ashwagandha) on Hematological and Biochemical Markers, Hormonal Behavior, and Oxidant Response in Healthy Adults: A Systematic Review
por: Gómez Afonso, Adrián, et al.
Publicado: (2023)

Ashwagandha-induced liver injury—A case series from India and literature review
por: Philips, Cyriac A., et al.
Publicado: (2023)

Paraquat and psychological stressor interactions as pertains to Parkinsonian co-morbidity
por: Rudyk, Chris, et al.
Publicado: (2015)

Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers
por: Raut, Ashwinikumar A., et al.
Publicado: (2012)

Studies on Ashwagandha Ghrita with reference to murcchana process and storage conditions
por: Gurav, Nilambari S., et al.
Publicado: (2020)

Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
por: Dutta, Rinku, et al.
Publicado: (2019)

Ashwagandha as a Unique Cause of Thyrotoxicosis Presenting With Supraventricular Tachycardia
por: Kamal, Hawra I, et al.
Publicado: (2022)

Ashwagandha‐induced acute liver injury: A case report
por: Tóth, Marcell, et al.
Publicado: (2023)

SAT435 The Quest Of Elevated Dhea-s: Is It A Tumor Or Is It Ashwagandha?
por: Patel, Shivani, et al.
Publicado: (2023)

Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics
por: Parashar, Krishan, et al.
Publicado: (2019)

Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2
por: Wang, Qingqing, et al.
Publicado: (2017)

Paraquat (Pesticides)
Publicado: (2022)

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease
por: Chaouhan, Hitesh Singh, et al.
Publicado: (2022)

Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity
por: Kumar, Praveen, et al.
Publicado: (2014)

Influence of lunar cycles on growth of Ashwagandha (Withania somnifera [L.] Dunal)
por: Tavhare, Swagata D., et al.
Publicado: (2015)

Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts
por: Kaul, Sunil C., et al.
Publicado: (2016)

Prediction of outcome after paraquat poisoning by measurement of the plasma paraquat concentration
por: Senarathna, L., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_mdjkou70gu342bggh001k2fd1c