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Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting
Peroxisomal matrix proteins are transported into peroxisomes in a fully-folded state, but whether multimeric proteins are imported as monomers or oligomers is still disputed. Here, we used alanine:glyoxylate aminotransferase (AGT), a homodimeric pyridoxal 5′-phosphate (PLP)-dependent enzyme, whose d...
Autores principales: | Dindo, Mirco, Ambrosini, Giulia, Oppici, Elisa, Pey, Angel L., O’Toole, Peter J., Marrison, Joanne L., Morrison, Ian E. G., Butturini, Elena, Grottelli, Silvia, Costantini, Claudio, Cellini, Barbara |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067440/ https://www.ncbi.nlm.nih.gov/pubmed/33917320 http://dx.doi.org/10.3390/jpm11040273 |
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