Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
Although coagulation disorders and immune/inflammatory response have been associated with the final outcome of patients with sepsis, their link with thetemporaryclinical deterioration or improvement of patients is unknown. We aimed to investigate this link. We prospectively included consecutive pati...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067680/ https://www.ncbi.nlm.nih.gov/pubmed/33917002 http://dx.doi.org/10.3390/jcm10081548 |
_version_ | 1783682859132780544 |
---|---|
author | Lavranou, Georgia-Athanasia Mentzelopoulos, Spyros Katsaounou, Paraskevi Siempos, Ilias Kalomenidis, Ioannis Geranaki, Aikaterini Routsi, Christina Zakynthinos, Spyros |
author_facet | Lavranou, Georgia-Athanasia Mentzelopoulos, Spyros Katsaounou, Paraskevi Siempos, Ilias Kalomenidis, Ioannis Geranaki, Aikaterini Routsi, Christina Zakynthinos, Spyros |
author_sort | Lavranou, Georgia-Athanasia |
collection | PubMed |
description | Although coagulation disorders and immune/inflammatory response have been associated with the final outcome of patients with sepsis, their link with thetemporaryclinical deterioration or improvement of patients is unknown. We aimed to investigate this link. We prospectively included consecutive patients admitted to the intensive care unit (ICU) with a suspected diagnosis of infection and evaluated within the first 24 h from admission. Blood levels of many cytokines and inflammatory and coagulation factors were measured and their predictive value was assessed by calculating the Area Under the Receiver Operating Characteristic (AUROC) curves. Patients (n = 102) were allocated in five groups, i.e., sepsis (n = 14), severe sepsis (n = 17), septic shock (n = 28), Systemic Inflammatory Response Syndrome (SIRS) without infection (n = 17), and trauma/surgery without SIRS or infection (n = 26). In septic shock, coagulation factors FVII and FIX and Protein C had AUROCs 0.67–0.78. In severe sepsis, Antithrombin III, Protein C, C-reactive protein, Procalcitonin and Thrombopoietin had AUROCs 0.73–0.75. In sepsis, Tumor Necrosis Factor a, and Interleukins 1β and 10 had AUROCs 0.66–0.72. In patients admitted to the ICU with a suspected diagnosis of infection, coagulation factors and inhibitors, as well as cytokine and inflammatory marker levels, have substantial predictive value in distinct groups of septic patients. |
format | Online Article Text |
id | pubmed-8067680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80676802021-04-25 Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? Lavranou, Georgia-Athanasia Mentzelopoulos, Spyros Katsaounou, Paraskevi Siempos, Ilias Kalomenidis, Ioannis Geranaki, Aikaterini Routsi, Christina Zakynthinos, Spyros J Clin Med Article Although coagulation disorders and immune/inflammatory response have been associated with the final outcome of patients with sepsis, their link with thetemporaryclinical deterioration or improvement of patients is unknown. We aimed to investigate this link. We prospectively included consecutive patients admitted to the intensive care unit (ICU) with a suspected diagnosis of infection and evaluated within the first 24 h from admission. Blood levels of many cytokines and inflammatory and coagulation factors were measured and their predictive value was assessed by calculating the Area Under the Receiver Operating Characteristic (AUROC) curves. Patients (n = 102) were allocated in five groups, i.e., sepsis (n = 14), severe sepsis (n = 17), septic shock (n = 28), Systemic Inflammatory Response Syndrome (SIRS) without infection (n = 17), and trauma/surgery without SIRS or infection (n = 26). In septic shock, coagulation factors FVII and FIX and Protein C had AUROCs 0.67–0.78. In severe sepsis, Antithrombin III, Protein C, C-reactive protein, Procalcitonin and Thrombopoietin had AUROCs 0.73–0.75. In sepsis, Tumor Necrosis Factor a, and Interleukins 1β and 10 had AUROCs 0.66–0.72. In patients admitted to the ICU with a suspected diagnosis of infection, coagulation factors and inhibitors, as well as cytokine and inflammatory marker levels, have substantial predictive value in distinct groups of septic patients. MDPI 2021-04-07 /pmc/articles/PMC8067680/ /pubmed/33917002 http://dx.doi.org/10.3390/jcm10081548 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lavranou, Georgia-Athanasia Mentzelopoulos, Spyros Katsaounou, Paraskevi Siempos, Ilias Kalomenidis, Ioannis Geranaki, Aikaterini Routsi, Christina Zakynthinos, Spyros Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? |
title | Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? |
title_full | Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? |
title_fullStr | Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? |
title_full_unstemmed | Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? |
title_short | Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? |
title_sort | can coagulation system disorders and cytokine and inflammatory marker levels predict the temporary clinical deterioration or improvement of septic patients on icu admission? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067680/ https://www.ncbi.nlm.nih.gov/pubmed/33917002 http://dx.doi.org/10.3390/jcm10081548 |
work_keys_str_mv | AT lavranougeorgiaathanasia cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission AT mentzelopoulosspyros cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission AT katsaounouparaskevi cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission AT siemposilias cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission AT kalomenidisioannis cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission AT geranakiaikaterini cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission AT routsichristina cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission AT zakynthinosspyros cancoagulationsystemdisordersandcytokineandinflammatorymarkerlevelspredictthetemporaryclinicaldeteriorationorimprovementofsepticpatientsonicuadmission |