Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?

Although coagulation disorders and immune/inflammatory response have been associated with the final outcome of patients with sepsis, their link with thetemporaryclinical deterioration or improvement of patients is unknown. We aimed to investigate this link. We prospectively included consecutive pati...

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Autores principales: Lavranou, Georgia-Athanasia, Mentzelopoulos, Spyros, Katsaounou, Paraskevi, Siempos, Ilias, Kalomenidis, Ioannis, Geranaki, Aikaterini, Routsi, Christina, Zakynthinos, Spyros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067680/
https://www.ncbi.nlm.nih.gov/pubmed/33917002
http://dx.doi.org/10.3390/jcm10081548
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author Lavranou, Georgia-Athanasia
Mentzelopoulos, Spyros
Katsaounou, Paraskevi
Siempos, Ilias
Kalomenidis, Ioannis
Geranaki, Aikaterini
Routsi, Christina
Zakynthinos, Spyros
author_facet Lavranou, Georgia-Athanasia
Mentzelopoulos, Spyros
Katsaounou, Paraskevi
Siempos, Ilias
Kalomenidis, Ioannis
Geranaki, Aikaterini
Routsi, Christina
Zakynthinos, Spyros
author_sort Lavranou, Georgia-Athanasia
collection PubMed
description Although coagulation disorders and immune/inflammatory response have been associated with the final outcome of patients with sepsis, their link with thetemporaryclinical deterioration or improvement of patients is unknown. We aimed to investigate this link. We prospectively included consecutive patients admitted to the intensive care unit (ICU) with a suspected diagnosis of infection and evaluated within the first 24 h from admission. Blood levels of many cytokines and inflammatory and coagulation factors were measured and their predictive value was assessed by calculating the Area Under the Receiver Operating Characteristic (AUROC) curves. Patients (n = 102) were allocated in five groups, i.e., sepsis (n = 14), severe sepsis (n = 17), septic shock (n = 28), Systemic Inflammatory Response Syndrome (SIRS) without infection (n = 17), and trauma/surgery without SIRS or infection (n = 26). In septic shock, coagulation factors FVII and FIX and Protein C had AUROCs 0.67–0.78. In severe sepsis, Antithrombin III, Protein C, C-reactive protein, Procalcitonin and Thrombopoietin had AUROCs 0.73–0.75. In sepsis, Tumor Necrosis Factor a, and Interleukins 1β and 10 had AUROCs 0.66–0.72. In patients admitted to the ICU with a suspected diagnosis of infection, coagulation factors and inhibitors, as well as cytokine and inflammatory marker levels, have substantial predictive value in distinct groups of septic patients.
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spelling pubmed-80676802021-04-25 Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission? Lavranou, Georgia-Athanasia Mentzelopoulos, Spyros Katsaounou, Paraskevi Siempos, Ilias Kalomenidis, Ioannis Geranaki, Aikaterini Routsi, Christina Zakynthinos, Spyros J Clin Med Article Although coagulation disorders and immune/inflammatory response have been associated with the final outcome of patients with sepsis, their link with thetemporaryclinical deterioration or improvement of patients is unknown. We aimed to investigate this link. We prospectively included consecutive patients admitted to the intensive care unit (ICU) with a suspected diagnosis of infection and evaluated within the first 24 h from admission. Blood levels of many cytokines and inflammatory and coagulation factors were measured and their predictive value was assessed by calculating the Area Under the Receiver Operating Characteristic (AUROC) curves. Patients (n = 102) were allocated in five groups, i.e., sepsis (n = 14), severe sepsis (n = 17), septic shock (n = 28), Systemic Inflammatory Response Syndrome (SIRS) without infection (n = 17), and trauma/surgery without SIRS or infection (n = 26). In septic shock, coagulation factors FVII and FIX and Protein C had AUROCs 0.67–0.78. In severe sepsis, Antithrombin III, Protein C, C-reactive protein, Procalcitonin and Thrombopoietin had AUROCs 0.73–0.75. In sepsis, Tumor Necrosis Factor a, and Interleukins 1β and 10 had AUROCs 0.66–0.72. In patients admitted to the ICU with a suspected diagnosis of infection, coagulation factors and inhibitors, as well as cytokine and inflammatory marker levels, have substantial predictive value in distinct groups of septic patients. MDPI 2021-04-07 /pmc/articles/PMC8067680/ /pubmed/33917002 http://dx.doi.org/10.3390/jcm10081548 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lavranou, Georgia-Athanasia
Mentzelopoulos, Spyros
Katsaounou, Paraskevi
Siempos, Ilias
Kalomenidis, Ioannis
Geranaki, Aikaterini
Routsi, Christina
Zakynthinos, Spyros
Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
title Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
title_full Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
title_fullStr Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
title_full_unstemmed Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
title_short Can Coagulation System Disorders and Cytokine and Inflammatory Marker Levels Predict the Temporary Clinical Deterioration or Improvement of Septic Patients on ICU Admission?
title_sort can coagulation system disorders and cytokine and inflammatory marker levels predict the temporary clinical deterioration or improvement of septic patients on icu admission?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067680/
https://www.ncbi.nlm.nih.gov/pubmed/33917002
http://dx.doi.org/10.3390/jcm10081548
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