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Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach

Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (M...

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Autores principales: Khan, Md Ishak, Hasan, Fuad, Mahmud, Khandakar Abu Hasan Al, Adnan, Ashfaq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067762/
https://www.ncbi.nlm.nih.gov/pubmed/33917073
http://dx.doi.org/10.3390/biom11040540
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author Khan, Md Ishak
Hasan, Fuad
Mahmud, Khandakar Abu Hasan Al
Adnan, Ashfaq
author_facet Khan, Md Ishak
Hasan, Fuad
Mahmud, Khandakar Abu Hasan Al
Adnan, Ashfaq
author_sort Khan, Md Ishak
collection PubMed
description Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (MD) simulations on NFs to extract their strain rate-dependent behavior. It is found that they are highly stretchable and show multiple stages of unfolding. Furthermore, NFs show high tensile stiffness. Also, viscoelastic modeling shows that they correspond to simplified viscoelastic models. This study effectively enhances the existent axonal models focusing on axonal injury.
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spelling pubmed-80677622021-04-25 Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach Khan, Md Ishak Hasan, Fuad Mahmud, Khandakar Abu Hasan Al Adnan, Ashfaq Biomolecules Article Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (MD) simulations on NFs to extract their strain rate-dependent behavior. It is found that they are highly stretchable and show multiple stages of unfolding. Furthermore, NFs show high tensile stiffness. Also, viscoelastic modeling shows that they correspond to simplified viscoelastic models. This study effectively enhances the existent axonal models focusing on axonal injury. MDPI 2021-04-07 /pmc/articles/PMC8067762/ /pubmed/33917073 http://dx.doi.org/10.3390/biom11040540 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khan, Md Ishak
Hasan, Fuad
Mahmud, Khandakar Abu Hasan Al
Adnan, Ashfaq
Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
title Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
title_full Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
title_fullStr Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
title_full_unstemmed Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
title_short Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
title_sort viscoelastic response of neurofilaments: an atomistic simulation approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067762/
https://www.ncbi.nlm.nih.gov/pubmed/33917073
http://dx.doi.org/10.3390/biom11040540
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