Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets

Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecu...

Descripción completa

Detalles Bibliográficos
Autores principales: Hosoya, Yusuke, Ohkanda, Junko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067799/
https://www.ncbi.nlm.nih.gov/pubmed/33917117
http://dx.doi.org/10.3390/molecules26082118
_version_ 1783682887218888704
author Hosoya, Yusuke
Ohkanda, Junko
author_facet Hosoya, Yusuke
Ohkanda, Junko
author_sort Hosoya, Yusuke
collection PubMed
description Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid–liquid phase separations—which critically involve both intermolecular interactions between IDPs and their posttranslational modification—are analyzed to understand the potential of IDPs as new drug targets.
format Online
Article
Text
id pubmed-8067799
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80677992021-04-25 Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets Hosoya, Yusuke Ohkanda, Junko Molecules Review Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid–liquid phase separations—which critically involve both intermolecular interactions between IDPs and their posttranslational modification—are analyzed to understand the potential of IDPs as new drug targets. MDPI 2021-04-07 /pmc/articles/PMC8067799/ /pubmed/33917117 http://dx.doi.org/10.3390/molecules26082118 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hosoya, Yusuke
Ohkanda, Junko
Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_full Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_fullStr Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_full_unstemmed Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_short Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_sort intrinsically disordered proteins as regulators of transient biological processes and as untapped drug targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067799/
https://www.ncbi.nlm.nih.gov/pubmed/33917117
http://dx.doi.org/10.3390/molecules26082118
work_keys_str_mv AT hosoyayusuke intrinsicallydisorderedproteinsasregulatorsoftransientbiologicalprocessesandasuntappeddrugtargets
AT ohkandajunko intrinsicallydisorderedproteinsasregulatorsoftransientbiologicalprocessesandasuntappeddrugtargets

Ejemplares similares