Cargando…

Successful Direct Acting Antiviral Therapy in Chronic Hepatitis C Normalizes IFNγ and IL2 Production in T Cells Together with TLR8 Expression and Functionality in Peripheral Blood Mononuclear Cells

Chronic hepatitis C infection (HCV) activates a systemic cell-mediated immune response characterized by the production of IFNγ and an innate immune response addressed by the activation of TLR signaling. We aimed to investigate whether HCV eradication by direct acting antivirals (DAA) leads to a reco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arias-Loste, María Teresa, Cabezas, Joaquín, Llerena, Susana, Iruzubieta, Paula, San-Segundo, David, Merino, David, Cuadrado, Antonio, Vaqué, José Pedro, López-Hoyos, Marcos, Crespo, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068025/ https://www.ncbi.nlm.nih.gov/pubmed/33917265 http://dx.doi.org/10.3390/v13040635

Ejemplares similares

Increased Expression Profile and Functionality of TLR6 in Peripheral Blood Mononuclear Cells and Hepatocytes of Morbidly Obese Patients with Non-Alcoholic Fatty Liver Disease
por: Arias-Loste, María Teresa, et al.
Publicado: (2016)

Changes in Circulating Lysyl Oxidase-Like-2 (LOXL2) Levels, HOMA, and Fibrosis after Sustained Virological Response by Direct Antiviral Therapy
por: Puente, Angela, et al.
Publicado: (2019)

LOXL2—A New Target in Antifibrogenic Therapy?
por: Puente, Angela, et al.
Publicado: (2019)

Innate and Adaptive Immunity Alterations in Metabolic Associated Fatty Liver Disease and Its Implication in COVID-19 Severity
por: Lamadrid, Patricia, et al.
Publicado: (2021)

Porto-Sinusoidal Vascular Disease Associated to Oxaliplatin: An Entity to Think about It
por: Puente, Angela, et al.
Publicado: (2019)

SARS-CoV-2 massive testing: A window of opportunity to catch up with HCV elimination
por: Crespo, Javier, et al.
Publicado: (2021)

Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding
por: Fortea, José Ignacio, et al.
Publicado: (2018)

Intraepithelial lymphocytes subsets in different forms of celiac disease
por: Sánchez-Castañon, M., et al.
Publicado: (2016)

Pathophysiological Mechanisms in Non-Alcoholic Fatty Liver Disease: From Drivers to Targets
por: Santos-Laso, Alvaro, et al.
Publicado: (2021)

Fatty Liver Disease, Metabolism and Alcohol Interplay: A Comprehensive Review
por: Odriozola, Aitor, et al.
Publicado: (2023)

The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?
por: Iruzubieta, Paula, et al.
Publicado: (2015)

The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease
por: Arias-Loste, María Teresa, et al.
Publicado: (2015)

Use of Protein Pegylation to Prolong the Antiviral Effect of IFN Against FMDV
por: Diaz-San Segundo, Fayna, et al.
Publicado: (2021)

High liver stiffness values by transient elastography related to metabolic syndrome and harmful alcohol use in a large Spanish cohort
por: Llop, Elba, et al.
Publicado: (2021)

Hepatitis C Micro-Elimination beyond Prison Walls: Navigator-Assisted Test-and-Treat Strategy for Subjects Serving Non-Custodial Sentences
por: Cabezas, Joaquin, et al.
Publicado: (2021)

Alteration of the IFN-Pathway by Human Papillomavirus Proteins: Antiviral Immune Response Evasion Mechanism
por: Castro-Muñoz, Leonardo Josué, et al.
Publicado: (2022)

Innovative Therapeutic Approaches in Non-Alcoholic Fatty Liver Disease: When Knowing Your Patient Is Key
por: Alonso-Peña, Marta, et al.
Publicado: (2023)

Faecal Microbiota Transplantation, Paving the Way to Treat Non-Alcoholic Fatty Liver Disease
por: Del Barrio, María, et al.
Publicado: (2023)

Is HCV elimination possible in prison?
por: Crespo, J., et al.
Publicado: (2017)

TLR-9, but not TLR-2, TLR-3 and TLR-4, is upregulated on peripheral blood mononuclear cells of patients with active systemic lupus erythematosus
por: Papadimitraki, ED, et al.
Publicado: (2005)

The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the Intestine
por: Su, Rui, et al.
Publicado: (2020)

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients
por: Serrano-Maciá, Marina, et al.
Publicado: (2022)

TLR Responses in Preterm and Term Infant Cord Blood Mononuclear Cells
por: Anderson, Jeremy, et al.
Publicado: (2023)

NFκB activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4
por: Ferrandez, Eva, et al.
Publicado: (2018)

Data regarding the effect of cannabis consumption on liver function in the prospective PAFIP cohort of first episode psychosis
por: Vázquez-Bourgon, Javier, et al.
Publicado: (2019)

Metabolic effects of reduced growth hormone action in fatty liver disease
por: Rufinatscha, Kerstin, et al.
Publicado: (2018)

Effects of Separate and Concomitant TLR-2 and TLR-4 Activation in Peripheral Blood Mononuclear Cells of Newborn and Adult Horses
por: Vendrig, Johannes Cornelis, et al.
Publicado: (2013)

Use of IFN-Based Biotherapeutics to Harness the Host Against Foot-And-Mouth Disease
por: Medina, Gisselle N., et al.
Publicado: (2020)

Epidemiology of intrafamilial inflammatory bowel disease throughout Europe
por: Arias-Loste, Maria Teresa, et al.
Publicado: (2012)

The effect of IFN-γ and TGF-β in the functional activity of mononuclear cells in the presence of Entamoeba histolytica
por: Moraes, Lucélia Campelo Albuquerque, et al.
Publicado: (2015)

Methods for studying antiviral functions of macrophages and mononuclear phagocytes
por: Keller, F.
Publicado: (1994)

Response of human periodontal ligament stem cells to IFN-γ and TLR-agonists
por: Andrukhov, Oleh, et al.
Publicado: (2017)

High Pretransplant BAFF Levels and B-cell Subset Polarized towards a Memory Phenotype as Predictive Biomarkers for Antibody-Mediated Rejection
por: Irure-Ventura, Juan, et al.
Publicado: (2020)

Clinical significance of TLR3 and TLR4 in peripheral blood mononuclear cells from children with Henoch-Schönlein purpura nephritis
por: CHANG, HONG, et al.
Publicado: (2014)

Atopy affects LPS responsiveness and TLR-4 expression in children peripheral mononuclear cells
por: Préfontaine, D, et al.
Publicado: (2010)

Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture
por: Ikeda, Hiroki, et al.
Publicado: (2015)

Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
por: Arias-Loste, María Teresa, et al.
Publicado: (2014)

Antiviral Activity of Porcine IFN-λ3 and IFN-α against Porcine Rotavirus In Vitro
por: Deng, Lishuang, et al.
Publicado: (2022)

Improvement in the definition of anti-HLA antibody profile in highly sensitized patients
por: Irure, Juan, et al.
Publicado: (2017)

The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures
por: Torvinen, Maria, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_gopgkammrc0o984ggubvs9f5qo