Cargando…

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling

The T cell antigen receptor (TCR) is expressed on T cells, which orchestrate adaptive immune responses. It is composed of the ligand-binding clonotypic TCRαβ heterodimer and the non-covalently bound invariant signal-transducing CD3 complex. Among the CD3 subunits, the CD3ε cytoplasmic tail contains...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hartl, Frederike A., Ngoenkam, Jatuporn, Beck-Garcia, Esmeralda, Cerqueira, Liz, Wipa, Piyamaporn, Paensuwan, Pussadee, Suriyaphol, Prapat, Mishra, Pankaj, Schraven, Burkhart, Günther, Stefan, Pongcharoen, Sutatip, Schamel, Wolfgang W. A., Minguet, Susana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068026/ https://www.ncbi.nlm.nih.gov/pubmed/33917227 http://dx.doi.org/10.3390/cells10040834

Ejemplares similares

Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells
por: Ngoenkam, Jatuporn, et al.
Publicado: (2021)

Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation
por: Ngoenkam, Jatuporn, et al.
Publicado: (2014)

Essential function of adaptor protein Nck1 in platelet-derived growth factor receptor signaling in human lens epithelial cells
por: Paensuwan, Pussadee, et al.
Publicado: (2022)

Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells
por: Nuiyen, Aussanee, et al.
Publicado: (2022)

Nitro Dihydrocapsaicin, a Non-Pungent Capsaicin Analogue, Inhibits Cellular Senescence of Lens Epithelial Cells via Upregulation of SIRT1
por: Paensuwan, Pussadee, et al.
Publicado: (2022)

Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor
por: Juraske, Claudia, et al.
Publicado: (2018)

Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy
por: Bommhardt, Ursula, et al.
Publicado: (2019)

Immunological responses and adverse reactions of the heterologous second booster dose of BNT162b2 after two-dose CoronaVac for COVID-19 vaccination in healthcare workers of Faculty of Medicine, Naresuan University
por: Makanut, Supawadee, et al.
Publicado: (2023)

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
por: Schultz, Annika, et al.
Publicado: (2022)

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions
por: Kästle, Matthias, et al.
Publicado: (2020)

The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37
por: Kowallik, Sarah, et al.
Publicado: (2020)

Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection
por: Kästle, Matthias, et al.
Publicado: (2022)

T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells
por: Hem, Cecilie Dahl, et al.
Publicado: (2015)

Stoichiometry and intracellular fate of TRIM-containing TCR complexes
por: Swamy, Mahima, et al.
Publicado: (2010)

TCR Triggering Induces the Formation of Lck–RACK1–Actinin-1 Multiprotein Network Affecting Lck Redistribution
por: Ballek, Ondřej, et al.
Publicado: (2016)

TCR-triggered extracellular superoxide production is not required for T-cell activation
por: Belikov, Aleksey V, et al.
Publicado: (2014)

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor
por: Casas, Javier, et al.
Publicado: (2014)

Lck Domains Differentially Contribute to Pre–T Cell Receptor (Tcr)–And TCR-α/β–Regulated Developmental Transitions
por: Lin, Kui, et al.
Publicado: (2000)

Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement
por: Filipp, Dominik, et al.
Publicado: (2012)

A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation
por: Lui, Victor G., et al.
Publicado: (2023)

The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain
por: Kirchgessner, Henning, et al.
Publicado: (2001)

Roles of the Src Tyrosine Kinases Lck and Fyn in Regulating γδTCR Signal Strength
por: Laird, Renee M., et al.
Publicado: (2010)

Nck by the numbers
por: Leslie, Mitch
Publicado: (2012)

The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling
por: Arndt, Börge, et al.
Publicado: (2011)

How ITD Insertion Sites Orchestrate the Biology and Disease of FLT3-ITD-Mutated Acute Myeloid Leukemia
por: Haage, Tobias R., et al.
Publicado: (2023)

Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells
por: Lipp, Anna M., et al.
Publicado: (2014)

TCR activation kinetics and feedback regulation in primary human T cells
por: Poltorak, Mateusz, et al.
Publicado: (2013)

Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development
por: Golding, Adam P., et al.
Publicado: (2023)

Serum Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Patients with Hepatocellular Carcinoma
por: Sripariwuth, Ekawee, et al.
Publicado: (2021)

Editorial: Community series in adaptor molecules in T cell signaling, volume II
por: Pongcharoen, Sutatip, et al.
Publicado: (2023)

Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling
por: Arulraj, Theinmozhi, et al.
Publicado: (2018)

Lck bound to coreceptor is less active than free Lck
por: Wei, Qianru, et al.
Publicado: (2020)

miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4(+) T Cells
por: Reddycherla, Amarendra V., et al.
Publicado: (2015)

Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
por: Harder, Thomas, et al.
Publicado: (2014)

HIV-1 Nef Employs Two Distinct Mechanisms to Modulate Lck Subcellular Localization and TCR Induced Actin Remodeling
por: Haller, Claudia, et al.
Publicado: (2007)

T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane
por: Bruyns, Eddy, et al.
Publicado: (1998)

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events
por: Dadwal, Nirdosh, et al.
Publicado: (2021)

Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice
por: Bywaters, Briana C., et al.
Publicado: (2022)

Fibroin and fibroin blended three-dimensional scaffolds for rat chondrocyte culture
por: Chomchalao, Pratthana, et al.
Publicado: (2013)

The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review)
por: Songjang, Worawat, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4evkl61h0obcsobe6u5rjpd90s