Cargando…

Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

Transactivation response DNA binding protein 43 kDa (TDP-43) is known to be a pathologic protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 is normally a nuclear protein, but affected neurons of ALS or FTLD patients exhibit mislocalization of nuclear...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riku, Yuichi, Seilhean, Danielle, Duyckaerts, Charles, Boluda, Susana, Iguchi, Yohei, Ishigaki, Shinsuke, Iwasaki, Yasushi, Yoshida, Mari, Sobue, Gen, Katsuno, Masahisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068029/ https://www.ncbi.nlm.nih.gov/pubmed/33917673 http://dx.doi.org/10.3390/ijms22083843

Ejemplares similares

TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
por: Riku, Yuichi, et al.
Publicado: (2022)

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
por: Oiwa, Kotaro, et al.
Publicado: (2023)

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons()
por: Honda, Daiyu, et al.
Publicado: (2013)

Corrigendum to “The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons” [FEBS Open Bio 4 (2014) 1–10]
por: Honda, Daiyu, et al.
Publicado: (2014)

RNP2 of RNA Recognition Motif 1 Plays a Central Role in the Aberrant Modification of TDP-43
por: Takagi, Shinnosuke, et al.
Publicado: (2013)

Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis
por: Tan, Rachel H., et al.
Publicado: (2017)

TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration
por: Dijkstra, Anke A., et al.
Publicado: (2023)

Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus
por: Sobue, Gen, et al.
Publicado: (2018)

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
por: Yousef, Ahmed, et al.
Publicado: (2017)

TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration
por: Buciuc, Marina, et al.
Publicado: (2022)

Concurrent tau pathologies in frontotemporal lobar degeneration with TDP‐43 pathology
por: Koga, Shunsuke, et al.
Publicado: (2021)

TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer’s disease and frontotemporal lobar degeneration
por: Foulds, Penelope, et al.
Publicado: (2008)

Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration
por: Seelaar, Harro, et al.
Publicado: (2009)

In vivo staging of frontotemporal lobar degeneration TDP-43 type C pathology
por: Bocchetta, Martina, et al.
Publicado: (2020)

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
por: Dang, Theresa N. T., et al.
Publicado: (2014)

A 43-kDa TDP-43 Species Is Present in Aggregates Associated with Frontotemporal Lobar Degeneration
por: Bosque, Patrick J., et al.
Publicado: (2013)

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
por: Urwin, Hazel, et al.
Publicado: (2010)

Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions
por: Rodríguez-Periñán, Guiomar, et al.
Publicado: (2023)

Nuclear Expression of TDP-43 Is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis
por: Yabata, Hiroyuki, et al.
Publicado: (2023)

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
por: Van Deerlin, Vivianna M., et al.
Publicado: (2010)

TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration
por: Lee, Samuel M, et al.
Publicado: (2019)

TDP-43 and Inflammation: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Bright, Fiona, et al.
Publicado: (2021)

Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion
por: Junttila, Anna, et al.
Publicado: (2016)

Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations
por: Kocerha, Jannet, et al.
Publicado: (2011)

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies
por: Goossens, Joery, et al.
Publicado: (2015)

Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy
por: Behrouzi, Roya, et al.
Publicado: (2016)

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions
por: Watanabe, Ryohei, et al.
Publicado: (2020)

The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients
por: Collins, Mahlon, et al.
Publicado: (2012)

TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia
por: Archbold, Hilary C., et al.
Publicado: (2018)

The important functional role of TDP-43 plays in amyotrophic lateral sclerosis-frontotemporal dementia
por: Chen, Liam
Publicado: (2020)

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
por: Porta, Sílvia, et al.
Publicado: (2018)

Molecular Pathways Involved in Frontotemporal Lobar Degeneration with TDP-43 Proteinopathy: What Can We Learn from Proteomics?
por: Mol, Merel O., et al.
Publicado: (2021)

Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions
por: Ishigaki, Shinsuke, et al.
Publicado: (2012)

FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
por: Fujioka, Yusuke, et al.
Publicado: (2013)

ERRATUM: FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
por: Fujioka, Yusuke, et al.
Publicado: (2013)

ERRATUM: Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions
por: Ishigaki, Shinsuke, et al.
Publicado: (2013)

Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching
por: Lu, Yubing, et al.
Publicado: (2009)

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia
por: Pasetto, Laura, et al.
Publicado: (2021)

Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration
por: Davidson, Yvonne S., et al.
Publicado: (2017)

c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis
por: Katsumata, Ryu, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_q55l0fss4nedcl1gmkfosc7sg0