Lipodystrophy as a Late Effect after Stem Cell Transplantation

Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy following hematopoietic stem cell transplantation (HSCT) have been described. In this review, we summarize the cases described so far and discuss...

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Detalles Bibliográficos
Autores principales: Tews, Daniel, Schulz, Ansgar, Denzer, Christian, von Schnurbein, Julia, Ceccarini, Giovanni, Debatin, Klaus-Michael, Wabitsch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068033/
https://www.ncbi.nlm.nih.gov/pubmed/33917653
http://dx.doi.org/10.3390/jcm10081559
Descripción
Sumario:Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy following hematopoietic stem cell transplantation (HSCT) have been described. In this review, we summarize the cases described so far and discuss potential underlying mechanisms of the disease. The findings suggest that HSCT-associated lipodystrophies may be seen as a novel form of acquired lipodystrophy.

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