Cargando…
Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016
Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the research field of intracellular signaling related to the second messenger molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP). Hence, non-invasive imaging of this enzyme class...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068090/ https://www.ncbi.nlm.nih.gov/pubmed/33917199 http://dx.doi.org/10.3390/ijms22083832 |
_version_ | 1783682954935926784 |
---|---|
author | Schröder, Susann Scheunemann, Matthias Wenzel, Barbara Brust, Peter |
author_facet | Schröder, Susann Scheunemann, Matthias Wenzel, Barbara Brust, Peter |
author_sort | Schröder, Susann |
collection | PubMed |
description | Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the research field of intracellular signaling related to the second messenger molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP). Hence, non-invasive imaging of this enzyme class by positron emission tomography (PET) using appropriate isoform-selective PDE radioligands is gaining importance. This methodology enables the in vivo diagnosis and staging of numerous diseases associated with altered PDE density or activity in the periphery and the central nervous system as well as the translational evaluation of novel PDE inhibitors as therapeutics. In this follow-up review, we summarize the efforts in the development of novel PDE radioligands and highlight (pre-)clinical insights from PET studies using already known PDE radioligands since 2016. |
format | Online Article Text |
id | pubmed-8068090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80680902021-04-25 Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016 Schröder, Susann Scheunemann, Matthias Wenzel, Barbara Brust, Peter Int J Mol Sci Review Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the research field of intracellular signaling related to the second messenger molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP). Hence, non-invasive imaging of this enzyme class by positron emission tomography (PET) using appropriate isoform-selective PDE radioligands is gaining importance. This methodology enables the in vivo diagnosis and staging of numerous diseases associated with altered PDE density or activity in the periphery and the central nervous system as well as the translational evaluation of novel PDE inhibitors as therapeutics. In this follow-up review, we summarize the efforts in the development of novel PDE radioligands and highlight (pre-)clinical insights from PET studies using already known PDE radioligands since 2016. MDPI 2021-04-07 /pmc/articles/PMC8068090/ /pubmed/33917199 http://dx.doi.org/10.3390/ijms22083832 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schröder, Susann Scheunemann, Matthias Wenzel, Barbara Brust, Peter Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016 |
title | Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016 |
title_full | Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016 |
title_fullStr | Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016 |
title_full_unstemmed | Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016 |
title_short | Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016 |
title_sort | challenges on cyclic nucleotide phosphodiesterases imaging with positron emission tomography: novel radioligands and (pre-)clinical insights since 2016 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068090/ https://www.ncbi.nlm.nih.gov/pubmed/33917199 http://dx.doi.org/10.3390/ijms22083832 |
work_keys_str_mv | AT schrodersusann challengesoncyclicnucleotidephosphodiesterasesimagingwithpositronemissiontomographynovelradioligandsandpreclinicalinsightssince2016 AT scheunemannmatthias challengesoncyclicnucleotidephosphodiesterasesimagingwithpositronemissiontomographynovelradioligandsandpreclinicalinsightssince2016 AT wenzelbarbara challengesoncyclicnucleotidephosphodiesterasesimagingwithpositronemissiontomographynovelradioligandsandpreclinicalinsightssince2016 AT brustpeter challengesoncyclicnucleotidephosphodiesterasesimagingwithpositronemissiontomographynovelradioligandsandpreclinicalinsightssince2016 |