PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting on the core components of the pathway. Despite being an established drug target and a hub for crosstalk regulation, little is known about dephosphorylation of MEK, the central kinase within the cascade. Here, we ide...

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Detalles Bibliográficos
Autores principales: Cho, Eunice, Lou, Hua Jane, Kuruvilla, Leena, Calderwood, David A., Turk, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068315/
https://www.ncbi.nlm.nih.gov/pubmed/33789117
http://dx.doi.org/10.1016/j.celrep.2021.108928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068315/
https://www.ncbi.nlm.nih.gov/pubmed/33789117
http://dx.doi.org/10.1016/j.celrep.2021.108928

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