Association of Body Condition Score and Score Change during the Late Dry Period on Temporal Patterns of Beta-Hydroxybutyrate Concentration and Milk Yield and Composition in Early Lactation of Dairy Cows

SIMPLE SUMMARY: In order to develop strategies to monitor and mitigate high incidences of hyperketonemia in dairy herds, the factors associated with the fluctuations of beta-hydroxybutyrate (BHB) concentration during early lactation need to be assessed. Body condition score (BCS), as well as the change in BCS during the late dry period are elements that are highly related to the mobilization of body reserves, and the proper adaptation during the transition period of dairy cattle. Our objective was to describe the pattern of blood BHB concentration and the development of hyperketonemia during the first 14 days of lactation on the basis of both a single measurement of BCS (−21 d) and the change in BCS during the late dry period. Additionally, we aimed to characterize the association between changes in BCS and milk yield and milk composition in the first monthly test. Our results suggest that changes in BCS are associated with fluctuations in BHB concentration during early lactation. In addition, we observed that cows with a loss in BCS greater than 0.5 units during the late dry period have a higher risk of having elevated BHB concentrations and incidence of hyperketonemia than cows with no change in BCS in the late dry period. Moreover, these cows also experienced lower milk production at the first monthly milk test. ABSTRACT: Monitoring the body condition score (BCS) of dairy cows is a management strategy that can assist dairy producers in decision-making. The BCS and its variations reflect the level of body fat reserves and fat mobilization throughout the different stages of lactation. Cows that mobilize excessive amounts of fat reserves in response to the increased energy requirements of the transition period are more likely to have higher beta-hydroxybutyrate (BHB) concentration in blood, leading to a higher incidence of hyperketonemia postpartum. In this study, our main objective was to evaluate how both BCS (at 21 d prior to the expected calving date, −21 BCS) and change in BCS during the late dry period (−21 d to calving, ∆BCS) are associated with temporal patterns of blood BHB concentrations during the first two weeks of lactation. Our secondary objective was to characterize the relationship between the change in BCS in the late dry period, and milk yield and milk composition in the first milk test postpartum. In this retrospective cohort study, we assessed BCS at 21 (±3) days before the expected calving date and within three days after calving. Blood BHB concentration was measured at days 3 (±1), 7 (±1), and 14 (±1) postpartum. Hyperketonemia (HYK) was defined as blood BHB ≥ 1.2 mmol/L. To evaluate how −21 BCS and ∆BCS during the late dry period were associated with BHB in early lactation, linear mixed-effects regression models with an unstructured covariate matrix were performed. The association between ∆BCS and incidence of postpartum HYK were determined using a multivariable log-binomial model. A linear regression model was used to evaluate the association between ∆BCS and milk yield and milk composition in the first monthly test-day. Covariates used for model adjustment include parity, season, and baseline BCS. We observed that cows with BCS ≥ 4.0 at 21 d before their expected calving date had the highest BHB concentration postpartum, but no evidence that BCS ≥ 4.0 at 21 d was associated with fluctuations of BHB over time. Cows that experienced a large BCS loss (larger than 0.5 units) during the late dry period had a 61% (95% CI: 1.04, 2.50) higher risk of developing HYK in early lactation and had higher BHB concentrations during early lactation compared with cows with no ∆BCS prepartum. These associations were observed independently of the BCS at −21 d prepartum (baseline). In addition, cows that lost more than 0.5 BCS unit in the late dry period produced 3.3 kg less milk (95% CI: −7.06, 0.45) at the first milk test compared to cows that had no ∆BCS during the late dry period. No evidence of an association between −21 BCS and ∆BCS in the late dry period and milk composition was observed in our study. These results suggest that dynamic measures of BCS during the late dry period, such as ∆BCS, are better at evaluating blood BHB patterns in early lactation than BCS measured at a single time point. Cows with larger BCS loss during the late dry period and with greater parity are more likely to have higher concentrations of blood BHB postpartum, with the highest concentrations reported at 7 d post-calving.