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Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models
Salivary gland tumors are a heterogeneous group of neoplasms representing less than 10% of all head and neck tumors. Among salivary gland tumors, salivary duct carcinoma (SDC) is a rare, but highly aggressive malignant tumor resembling ductal breast carcinoma. Sublingual treatments are promising for...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068355/ https://www.ncbi.nlm.nih.gov/pubmed/33917958 http://dx.doi.org/10.3390/cells10040845 |
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author | Ciccolella, Maria Andreone, Sara Mancini, Jacopo Sestili, Paola Negri, Donatella Pacca, Anna Maria D’Urso, Maria Teresa Macchia, Daniele Canese, Rossella Pang, Ken SaiYing Ko, Thomas Decadt, Yves Schiavoni, Giovanna Mattei, Fabrizio Belardelli, Filippo Aricò, Eleonora Bracci, Laura |
author_facet | Ciccolella, Maria Andreone, Sara Mancini, Jacopo Sestili, Paola Negri, Donatella Pacca, Anna Maria D’Urso, Maria Teresa Macchia, Daniele Canese, Rossella Pang, Ken SaiYing Ko, Thomas Decadt, Yves Schiavoni, Giovanna Mattei, Fabrizio Belardelli, Filippo Aricò, Eleonora Bracci, Laura |
author_sort | Ciccolella, Maria |
collection | PubMed |
description | Salivary gland tumors are a heterogeneous group of neoplasms representing less than 10% of all head and neck tumors. Among salivary gland tumors, salivary duct carcinoma (SDC) is a rare, but highly aggressive malignant tumor resembling ductal breast carcinoma. Sublingual treatments are promising for SDC due to the induction of both local and systemic biological effects and to reduced systemic toxicity compared to other administration routes. In the present study, we first established that the sublingual administration of type I IFN (IFN-I) is safe and feasible, and exerts antitumor effects both as monotherapy and in combination with chemotherapy in transplantable tumor models, i.e., B16-OVA melanoma and EG.7-OVA lymphoma. Subsequently, we proved that sublingual IFN-I in combination with cyclophosphamide (CTX) induces a long-lasting reduction of tumor mass in NeuT transgenic mice that spontaneously develop SDC. Most importantly, tumor shrinkage in NeuT transgenic micewas accompanied by the emergence of tumor-specific cellular immune responses both in the blood and in the tumor tissue. Altogether, these results provide evidence that sublingual IFN holds promise in combination with chemotherapy for the treatment of cancer. |
format | Online Article Text |
id | pubmed-8068355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80683552021-04-25 Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models Ciccolella, Maria Andreone, Sara Mancini, Jacopo Sestili, Paola Negri, Donatella Pacca, Anna Maria D’Urso, Maria Teresa Macchia, Daniele Canese, Rossella Pang, Ken SaiYing Ko, Thomas Decadt, Yves Schiavoni, Giovanna Mattei, Fabrizio Belardelli, Filippo Aricò, Eleonora Bracci, Laura Cells Article Salivary gland tumors are a heterogeneous group of neoplasms representing less than 10% of all head and neck tumors. Among salivary gland tumors, salivary duct carcinoma (SDC) is a rare, but highly aggressive malignant tumor resembling ductal breast carcinoma. Sublingual treatments are promising for SDC due to the induction of both local and systemic biological effects and to reduced systemic toxicity compared to other administration routes. In the present study, we first established that the sublingual administration of type I IFN (IFN-I) is safe and feasible, and exerts antitumor effects both as monotherapy and in combination with chemotherapy in transplantable tumor models, i.e., B16-OVA melanoma and EG.7-OVA lymphoma. Subsequently, we proved that sublingual IFN-I in combination with cyclophosphamide (CTX) induces a long-lasting reduction of tumor mass in NeuT transgenic mice that spontaneously develop SDC. Most importantly, tumor shrinkage in NeuT transgenic micewas accompanied by the emergence of tumor-specific cellular immune responses both in the blood and in the tumor tissue. Altogether, these results provide evidence that sublingual IFN holds promise in combination with chemotherapy for the treatment of cancer. MDPI 2021-04-08 /pmc/articles/PMC8068355/ /pubmed/33917958 http://dx.doi.org/10.3390/cells10040845 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ciccolella, Maria Andreone, Sara Mancini, Jacopo Sestili, Paola Negri, Donatella Pacca, Anna Maria D’Urso, Maria Teresa Macchia, Daniele Canese, Rossella Pang, Ken SaiYing Ko, Thomas Decadt, Yves Schiavoni, Giovanna Mattei, Fabrizio Belardelli, Filippo Aricò, Eleonora Bracci, Laura Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models |
title | Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models |
title_full | Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models |
title_fullStr | Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models |
title_full_unstemmed | Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models |
title_short | Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models |
title_sort | anticancer effects of sublingual type i ifn in combination with chemotherapy in implantable and spontaneous tumor models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068355/ https://www.ncbi.nlm.nih.gov/pubmed/33917958 http://dx.doi.org/10.3390/cells10040845 |
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