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Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation

Aggregates of TAR DNA-binding protein (TDP-43) are a hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although TDP-43 aggregates are an undisputed pathological species at the end stage of these diseases, the molecular changes underlying the initiation o...

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Detalles Bibliográficos
Autores principales:	Pakravan, Donya, Michiels, Emiel, Bratek-Skicki, Anna, De Decker, Mathias, Van Lindt, Joris, Alsteens, David, Derclaye, Sylvie, Van Damme, Philip, Schymkowitz, Joost, Rousseau, Frederic, Tompa, Peter, Van Den Bosch, Ludo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068378/ https://www.ncbi.nlm.nih.gov/pubmed/33917983 http://dx.doi.org/10.3390/biom11040548

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