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Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction

Background: This study aimed to investigate the adding value of MRI over CT for preoperative cytoreductive surgery with hyperthermic intraperitoneal chemotherapies (CRS/HIPEC). Methods: Imaging and intraoperative peritoneal cancer index (PCI) were calculated in 62 patients with peritoneal metastasis...

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Autores principales: Lin, Chia-Ni, Huang, Weh-Shih, Huang, Tzu-Hao, Chen, Chao-Yu, Huang, Cheng-Yi, Wang, Ting-Yao, Liao, Yu-San, Lee, Li-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068380/
https://www.ncbi.nlm.nih.gov/pubmed/33917997
http://dx.doi.org/10.3390/diagnostics11040674
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author Lin, Chia-Ni
Huang, Weh-Shih
Huang, Tzu-Hao
Chen, Chao-Yu
Huang, Cheng-Yi
Wang, Ting-Yao
Liao, Yu-San
Lee, Li-Wen
author_facet Lin, Chia-Ni
Huang, Weh-Shih
Huang, Tzu-Hao
Chen, Chao-Yu
Huang, Cheng-Yi
Wang, Ting-Yao
Liao, Yu-San
Lee, Li-Wen
author_sort Lin, Chia-Ni
collection PubMed
description Background: This study aimed to investigate the adding value of MRI over CT for preoperative cytoreductive surgery with hyperthermic intraperitoneal chemotherapies (CRS/HIPEC). Methods: Imaging and intraoperative peritoneal cancer index (PCI) were calculated in 62 patients with peritoneal metastasis. Predictive models for the completeness of cytoreductive score using PCI data were established using decision tree algorithms. Results: In gastric cancer patients, a large discrepancy and poor agreement was appreciated between CT and surgical PCI, and a nonsignificant difference was noted between MRI and surgical PCI. In colon cancer patients, a better agreement and higher correlation with a smaller error was observed in PCI score using MRI than in that using CT. However, the addition of MRI to CT was limited for appendiceal and ovarian cancer patients. For predicting incomplete cytoreduction, CT models yielded inadequate accuracy while MRI models were more accurate with fair discrimination ability. Conclusions: CT was suitable for estimating PCI and surgery outcome in appendiceal and ovarian cancer patients, while further MRI in addition to CT was recommended for colon and gastric cancer patients. However, for classifying patients with peritoneal carcinomatosis into complete and incomplete cytoreduction, MRI was more effective than CT.
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spelling pubmed-80683802021-04-25 Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction Lin, Chia-Ni Huang, Weh-Shih Huang, Tzu-Hao Chen, Chao-Yu Huang, Cheng-Yi Wang, Ting-Yao Liao, Yu-San Lee, Li-Wen Diagnostics (Basel) Article Background: This study aimed to investigate the adding value of MRI over CT for preoperative cytoreductive surgery with hyperthermic intraperitoneal chemotherapies (CRS/HIPEC). Methods: Imaging and intraoperative peritoneal cancer index (PCI) were calculated in 62 patients with peritoneal metastasis. Predictive models for the completeness of cytoreductive score using PCI data were established using decision tree algorithms. Results: In gastric cancer patients, a large discrepancy and poor agreement was appreciated between CT and surgical PCI, and a nonsignificant difference was noted between MRI and surgical PCI. In colon cancer patients, a better agreement and higher correlation with a smaller error was observed in PCI score using MRI than in that using CT. However, the addition of MRI to CT was limited for appendiceal and ovarian cancer patients. For predicting incomplete cytoreduction, CT models yielded inadequate accuracy while MRI models were more accurate with fair discrimination ability. Conclusions: CT was suitable for estimating PCI and surgery outcome in appendiceal and ovarian cancer patients, while further MRI in addition to CT was recommended for colon and gastric cancer patients. However, for classifying patients with peritoneal carcinomatosis into complete and incomplete cytoreduction, MRI was more effective than CT. MDPI 2021-04-08 /pmc/articles/PMC8068380/ /pubmed/33917997 http://dx.doi.org/10.3390/diagnostics11040674 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Chia-Ni
Huang, Weh-Shih
Huang, Tzu-Hao
Chen, Chao-Yu
Huang, Cheng-Yi
Wang, Ting-Yao
Liao, Yu-San
Lee, Li-Wen
Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction
title Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction
title_full Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction
title_fullStr Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction
title_full_unstemmed Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction
title_short Adding Value of MRI over CT in Predicting Peritoneal Cancer Index and Completeness of Cytoreduction
title_sort adding value of mri over ct in predicting peritoneal cancer index and completeness of cytoreduction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068380/
https://www.ncbi.nlm.nih.gov/pubmed/33917997
http://dx.doi.org/10.3390/diagnostics11040674
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