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Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study

BACKGROUND: The Global Burden of Diseases Study 2017 predicted that chronic obstructive pulmonary disease (COPD) is the second leading cause of death, the fourth leading cause of premature death, and the third cause for DALYs lost in Nepal. However, data on the population-based prevalence of COPD in...

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Autores principales: Karki, Khem Bahadur, Poudyal, Anil, Shrestha, Namuna, Mahato, Namra Kumar, Aryal, Krishna Kumar, Sijapati, Milesh Jung, Bista, Bihungum, Gautam, Nitisha, Subedi, Ranjeeta, Siddiquee, Noor Kutubul Alam, Gyanwali, Pradip, Kuch, Ulrich, Groneberg, David A, Jha, Anjani Kumar, Dhimal, Meghnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068482/
https://www.ncbi.nlm.nih.gov/pubmed/33907397
http://dx.doi.org/10.2147/COPD.S295321
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author Karki, Khem Bahadur
Poudyal, Anil
Shrestha, Namuna
Mahato, Namra Kumar
Aryal, Krishna Kumar
Sijapati, Milesh Jung
Bista, Bihungum
Gautam, Nitisha
Subedi, Ranjeeta
Siddiquee, Noor Kutubul Alam
Gyanwali, Pradip
Kuch, Ulrich
Groneberg, David A
Jha, Anjani Kumar
Dhimal, Meghnath
author_facet Karki, Khem Bahadur
Poudyal, Anil
Shrestha, Namuna
Mahato, Namra Kumar
Aryal, Krishna Kumar
Sijapati, Milesh Jung
Bista, Bihungum
Gautam, Nitisha
Subedi, Ranjeeta
Siddiquee, Noor Kutubul Alam
Gyanwali, Pradip
Kuch, Ulrich
Groneberg, David A
Jha, Anjani Kumar
Dhimal, Meghnath
author_sort Karki, Khem Bahadur
collection PubMed
description BACKGROUND: The Global Burden of Diseases Study 2017 predicted that chronic obstructive pulmonary disease (COPD) is the second leading cause of death, the fourth leading cause of premature death, and the third cause for DALYs lost in Nepal. However, data on the population-based prevalence of COPD in Nepal are very limited. This study aims to assess the prevalence of COPD and factors associated with the occurrence of COPD in Nepal. METHODS: From a nationally representative, population-based cross-sectional study on chronic non-communicable diseases, the prevalence of COPD and its associated factors was determined. Of 12,557 participants aged over 20 years, 8945 participants completed a questionnaire and spirometry. Eligible participants were also asked to answer a COPD diagnostic questionnaire for screening COPD cases, and if needed underwent pre-bronchodilator and post-bronchodilator spirometry. COPD was defined as a post-bronchodilator FEV1/FVC (forced expiratory volume in 1 s/forced vital capacity) ratio of <0.70. Multivariate logistic regression was performed to identify factors associated with COPD. Sampling weights were used for all data analyses. RESULTS: The prevalence of COPD in Nepal was 11.7% (95% CI: 10.5% to 12.9 %), which increased with age, and higher in those with a low educational level, those who had smoked ≥50 pack-years, persons having a low body mass index (BMI), and residents of Karnali province. Multivariate analysis revealed that being aged 60 years and above, having a low BMI, low educational status, having smoked more than 50 pack-years, provincial distribution, and ethnicity were independent predictors of COPD. CONCLUSION: COPD is a growing and serious public health issue in Nepal. Factor such as old age, cigarette smoking, low educational attainment, low BMI, ethnicity, and locality of residence (province-level variation) plays a vital role in the occurrence of COPD. Strategies aimed at targeting these risk factors through health promotion and education interventions are needed to decrease the burden of COPD.
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spelling pubmed-80684822021-04-26 Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study Karki, Khem Bahadur Poudyal, Anil Shrestha, Namuna Mahato, Namra Kumar Aryal, Krishna Kumar Sijapati, Milesh Jung Bista, Bihungum Gautam, Nitisha Subedi, Ranjeeta Siddiquee, Noor Kutubul Alam Gyanwali, Pradip Kuch, Ulrich Groneberg, David A Jha, Anjani Kumar Dhimal, Meghnath Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: The Global Burden of Diseases Study 2017 predicted that chronic obstructive pulmonary disease (COPD) is the second leading cause of death, the fourth leading cause of premature death, and the third cause for DALYs lost in Nepal. However, data on the population-based prevalence of COPD in Nepal are very limited. This study aims to assess the prevalence of COPD and factors associated with the occurrence of COPD in Nepal. METHODS: From a nationally representative, population-based cross-sectional study on chronic non-communicable diseases, the prevalence of COPD and its associated factors was determined. Of 12,557 participants aged over 20 years, 8945 participants completed a questionnaire and spirometry. Eligible participants were also asked to answer a COPD diagnostic questionnaire for screening COPD cases, and if needed underwent pre-bronchodilator and post-bronchodilator spirometry. COPD was defined as a post-bronchodilator FEV1/FVC (forced expiratory volume in 1 s/forced vital capacity) ratio of <0.70. Multivariate logistic regression was performed to identify factors associated with COPD. Sampling weights were used for all data analyses. RESULTS: The prevalence of COPD in Nepal was 11.7% (95% CI: 10.5% to 12.9 %), which increased with age, and higher in those with a low educational level, those who had smoked ≥50 pack-years, persons having a low body mass index (BMI), and residents of Karnali province. Multivariate analysis revealed that being aged 60 years and above, having a low BMI, low educational status, having smoked more than 50 pack-years, provincial distribution, and ethnicity were independent predictors of COPD. CONCLUSION: COPD is a growing and serious public health issue in Nepal. Factor such as old age, cigarette smoking, low educational attainment, low BMI, ethnicity, and locality of residence (province-level variation) plays a vital role in the occurrence of COPD. Strategies aimed at targeting these risk factors through health promotion and education interventions are needed to decrease the burden of COPD. Dove 2021-04-20 /pmc/articles/PMC8068482/ /pubmed/33907397 http://dx.doi.org/10.2147/COPD.S295321 Text en © 2021 Karki et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Karki, Khem Bahadur
Poudyal, Anil
Shrestha, Namuna
Mahato, Namra Kumar
Aryal, Krishna Kumar
Sijapati, Milesh Jung
Bista, Bihungum
Gautam, Nitisha
Subedi, Ranjeeta
Siddiquee, Noor Kutubul Alam
Gyanwali, Pradip
Kuch, Ulrich
Groneberg, David A
Jha, Anjani Kumar
Dhimal, Meghnath
Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study
title Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study
title_full Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study
title_fullStr Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study
title_full_unstemmed Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study
title_short Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study
title_sort factors associated with chronic obstructive pulmonary diseases in nepal: evidence from a nationally representative population-based study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068482/
https://www.ncbi.nlm.nih.gov/pubmed/33907397
http://dx.doi.org/10.2147/COPD.S295321
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