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Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment
INTRODUCTION: The incidence of Alzheimer’s disease is on the rise, early detection of cognitive impairment of the elderly is very important. In traditional Chinese medicine, constitution is related to the susceptibility of the human body to diseases. Based on the theory of constitution of traditiona...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068505/ https://www.ncbi.nlm.nih.gov/pubmed/33907404 http://dx.doi.org/10.2147/NDT.S290692 |
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author | Deng, Xiangming Teng, Jinlong Nong, Xiucheng Yu, Bihan Tang, Liying Liang, Jinsong Zou, Zhuocheng Liu, Qiang Zhou, Lu Li, Qirong Zhao, Lihua |
author_facet | Deng, Xiangming Teng, Jinlong Nong, Xiucheng Yu, Bihan Tang, Liying Liang, Jinsong Zou, Zhuocheng Liu, Qiang Zhou, Lu Li, Qirong Zhao, Lihua |
author_sort | Deng, Xiangming |
collection | PubMed |
description | INTRODUCTION: The incidence of Alzheimer’s disease is on the rise, early detection of cognitive impairment of the elderly is very important. In traditional Chinese medicine, constitution is related to the susceptibility of the human body to diseases. Based on the theory of constitution of traditional Chinese medicine (TCM), the human population can be classified into 9 constitutions. However, little is known about the characteristics of medical constitution and related biomarkers in subjects with mild cognitive impairment (MCI). METHODS: We measured the TCM Constitution of 214 subjects by using the Constitution in Chinese Medicine Questionnaire (CCMQ). MMSE and MoCA were used to assess cognitive function. The subjects were divided into mild cognitive impairment group (MCI, n = 152) and normal control group (NC, n = 62). The levels of serum Hcy and serum/urine 8-iso-PGF 2α were determined. RESULTS: 1) It was found that there was a significant difference in constitution types between MCI and NC. There were significant differences in MMSE and MoCA score, serum Hcy and serum/urine 8-iso-PGF 2a levels between the two groups. 2) In logistic regression analysis, the variables with statistical significance were TCM Constitution of Yang-Deficient, Phlegm-Dampness, Blood-Stasis and abnormal increase of Hcy (OR>1). 3) The MoCA scores had a positive correlation with the MMSE. A statistically significant inverse association was found between serum Hcy, blood and urine 8-iso-PGF 2a and scores of cognitive assessment in MCI. CONCLUSION: Constitution types (Yang-Deficient, Phlegm-Dampness and Blood-Stasis) and abnormal serum Hcy elevation can be used as risk factors for MCI. MoCA scores can serve to detect MCI at early stage. Serum/urine 8-iso-PGF 2α has a certain relationship with MCI. Higher levels of serum/urine 8-iso–PGF 2α are more likely to be associated with MCI risk. |
format | Online Article Text |
id | pubmed-8068505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-80685052021-04-26 Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment Deng, Xiangming Teng, Jinlong Nong, Xiucheng Yu, Bihan Tang, Liying Liang, Jinsong Zou, Zhuocheng Liu, Qiang Zhou, Lu Li, Qirong Zhao, Lihua Neuropsychiatr Dis Treat Original Research INTRODUCTION: The incidence of Alzheimer’s disease is on the rise, early detection of cognitive impairment of the elderly is very important. In traditional Chinese medicine, constitution is related to the susceptibility of the human body to diseases. Based on the theory of constitution of traditional Chinese medicine (TCM), the human population can be classified into 9 constitutions. However, little is known about the characteristics of medical constitution and related biomarkers in subjects with mild cognitive impairment (MCI). METHODS: We measured the TCM Constitution of 214 subjects by using the Constitution in Chinese Medicine Questionnaire (CCMQ). MMSE and MoCA were used to assess cognitive function. The subjects were divided into mild cognitive impairment group (MCI, n = 152) and normal control group (NC, n = 62). The levels of serum Hcy and serum/urine 8-iso-PGF 2α were determined. RESULTS: 1) It was found that there was a significant difference in constitution types between MCI and NC. There were significant differences in MMSE and MoCA score, serum Hcy and serum/urine 8-iso-PGF 2a levels between the two groups. 2) In logistic regression analysis, the variables with statistical significance were TCM Constitution of Yang-Deficient, Phlegm-Dampness, Blood-Stasis and abnormal increase of Hcy (OR>1). 3) The MoCA scores had a positive correlation with the MMSE. A statistically significant inverse association was found between serum Hcy, blood and urine 8-iso-PGF 2a and scores of cognitive assessment in MCI. CONCLUSION: Constitution types (Yang-Deficient, Phlegm-Dampness and Blood-Stasis) and abnormal serum Hcy elevation can be used as risk factors for MCI. MoCA scores can serve to detect MCI at early stage. Serum/urine 8-iso-PGF 2α has a certain relationship with MCI. Higher levels of serum/urine 8-iso–PGF 2α are more likely to be associated with MCI risk. Dove 2021-04-20 /pmc/articles/PMC8068505/ /pubmed/33907404 http://dx.doi.org/10.2147/NDT.S290692 Text en © 2021 Deng et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Deng, Xiangming Teng, Jinlong Nong, Xiucheng Yu, Bihan Tang, Liying Liang, Jinsong Zou, Zhuocheng Liu, Qiang Zhou, Lu Li, Qirong Zhao, Lihua Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment |
title | Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment |
title_full | Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment |
title_fullStr | Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment |
title_full_unstemmed | Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment |
title_short | Characteristics of TCM Constitution and Related Biomarkers for Mild Cognitive Impairment |
title_sort | characteristics of tcm constitution and related biomarkers for mild cognitive impairment |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068505/ https://www.ncbi.nlm.nih.gov/pubmed/33907404 http://dx.doi.org/10.2147/NDT.S290692 |
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