Rituximab Treatment in Acute Disseminated Encephalomyelitis Associated with Salmonella Infection

Acute disseminated encephalomyelitis (ADEM) is an inflammatory, demyelinating, and rapidly progressive disorder of the central nervous system. This condition is also known as postinfectious encephalomyelitis, and it is characterized by multifocal lesions in the brain and spinal cord with widespread...

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Detalles Bibliográficos
Autores principales: Kacmaz, Ebru, Bozan, Gurkan, Carman, Kursat Bora, Kilic, Omer, Arslanoglu, Mehmet Ozgur, Toprak, Ugur, Kavaz Tufan, Aslı, Yarar, Coskun, Dinleyici, Ener Cagri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068525/
https://www.ncbi.nlm.nih.gov/pubmed/33954003
http://dx.doi.org/10.1155/2021/5570566
Descripción
Sumario:Acute disseminated encephalomyelitis (ADEM) is an inflammatory, demyelinating, and rapidly progressive disorder of the central nervous system. This condition is also known as postinfectious encephalomyelitis, and it is characterized by multifocal lesions in the brain and spinal cord with widespread neurological findings. High doses of intravenous (IV) methylprednisolone, intravenous immunoglobulin (IVIG), and plasma exchange (PLEX) treatments comprise the first-line therapy. There are limited pediatric case reports refractory to standard treatment. Here, we present the case of a 17-year-old girl diagnosed with ADEM associated with Salmonella infection, which was treated with rituximab.

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