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Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice

Chronic inflammation plays an essential role in the pathogenesis of abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation. Chemerin, a multifunctional adipocytokine, is mainly generated in the liver and adipose tissue. The combination of chemerin and chemokine-like recep...

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Autores principales: Chen, Shuxiao, Han, Chenglin, Bian, Shuai, Chen, Jianfeng, Feng, Xuedong, Li, Gang, Wu, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068550/
https://www.ncbi.nlm.nih.gov/pubmed/33953746
http://dx.doi.org/10.1155/2021/6629204
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author Chen, Shuxiao
Han, Chenglin
Bian, Shuai
Chen, Jianfeng
Feng, Xuedong
Li, Gang
Wu, Xuejun
author_facet Chen, Shuxiao
Han, Chenglin
Bian, Shuai
Chen, Jianfeng
Feng, Xuedong
Li, Gang
Wu, Xuejun
author_sort Chen, Shuxiao
collection PubMed
description Chronic inflammation plays an essential role in the pathogenesis of abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation. Chemerin, a multifunctional adipocytokine, is mainly generated in the liver and adipose tissue. The combination of chemerin and chemokine-like receptor 1 (CMKLR1) has been demonstrated to promote the progression of atherosclerosis, arthritis diseases, and Crohn's disease. However, chemerin-9 acts as an analog of chemerin to exert an anti-inflammatory effect by binding to CMKLR1. Here, we first demonstrated that AAA exhibited higher levels of chemerin and CMKLR1 expression compared with the normal aortic tissues. Hence, we hypothesized that the chemerin/CMKLR1 axis might be involved in AAA progression. Moreover, we found that chemerin-9 treatment markedly suppressed inflammatory cell infiltration, neovascularization, and matrix metalloproteinase (MMP) expression, while increasing the elastic fibers and smooth muscle cells (SMCs) in Ang II-induced AAA in ApoE(−/−) mice. This demonstrated that chemerin-9 could inhibit AAA formation. Collectively, our findings indicate a potential mechanism underlying AAA progression and suggest that chemerin-9 can be used therapeutically.
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spelling pubmed-80685502021-05-04 Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice Chen, Shuxiao Han, Chenglin Bian, Shuai Chen, Jianfeng Feng, Xuedong Li, Gang Wu, Xuejun J Oncol Research Article Chronic inflammation plays an essential role in the pathogenesis of abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation. Chemerin, a multifunctional adipocytokine, is mainly generated in the liver and adipose tissue. The combination of chemerin and chemokine-like receptor 1 (CMKLR1) has been demonstrated to promote the progression of atherosclerosis, arthritis diseases, and Crohn's disease. However, chemerin-9 acts as an analog of chemerin to exert an anti-inflammatory effect by binding to CMKLR1. Here, we first demonstrated that AAA exhibited higher levels of chemerin and CMKLR1 expression compared with the normal aortic tissues. Hence, we hypothesized that the chemerin/CMKLR1 axis might be involved in AAA progression. Moreover, we found that chemerin-9 treatment markedly suppressed inflammatory cell infiltration, neovascularization, and matrix metalloproteinase (MMP) expression, while increasing the elastic fibers and smooth muscle cells (SMCs) in Ang II-induced AAA in ApoE(−/−) mice. This demonstrated that chemerin-9 could inhibit AAA formation. Collectively, our findings indicate a potential mechanism underlying AAA progression and suggest that chemerin-9 can be used therapeutically. Hindawi 2021-04-17 /pmc/articles/PMC8068550/ /pubmed/33953746 http://dx.doi.org/10.1155/2021/6629204 Text en Copyright © 2021 Shuxiao Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Shuxiao
Han, Chenglin
Bian, Shuai
Chen, Jianfeng
Feng, Xuedong
Li, Gang
Wu, Xuejun
Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice
title Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice
title_full Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice
title_fullStr Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice
title_full_unstemmed Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice
title_short Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE(−/−) Mice
title_sort chemerin-9 attenuates experimental abdominal aortic aneurysm formation in apoe(−/−) mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068550/
https://www.ncbi.nlm.nih.gov/pubmed/33953746
http://dx.doi.org/10.1155/2021/6629204
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