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From workplace to home environment: spreading of mouse allergens by laboratory animal workers
PURPOSE: Laboratory animal workers (LAW) working with laboratory mice are exposed to mouse allergens (MA). If MA are spread to home environments, this might increase the risk for allergies in LAW and their families. This study aimed to assess 1. whether spreading of MA from workplace to home environ...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068679/ https://www.ncbi.nlm.nih.gov/pubmed/33219477 http://dx.doi.org/10.1007/s00420-020-01603-9 |
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author | Kube, Hannah Herrera, Ronald Dietrich-Gümperlein, Gisela Schierl, Rudolf Nowak, Dennis Radon, Katja Wengenroth, Laura Gerlich, Jessica |
author_facet | Kube, Hannah Herrera, Ronald Dietrich-Gümperlein, Gisela Schierl, Rudolf Nowak, Dennis Radon, Katja Wengenroth, Laura Gerlich, Jessica |
author_sort | Kube, Hannah |
collection | PubMed |
description | PURPOSE: Laboratory animal workers (LAW) working with laboratory mice are exposed to mouse allergens (MA). If MA are spread to home environments, this might increase the risk for allergies in LAW and their families. This study aimed to assess 1. whether spreading of MA from workplace to home environment takes place; 2. which factors increase spreading of MA. METHODS: In a cross-sectional study, dust samples were taken on the mattress and seating in homes of LAW (n = 105) and an unexposed comparison group (n = 13). From 89 LAW, additional dust samples were taken from their workplaces. Samples were analysed using Mus m1 ELISA kits [detection limit (DL) 0.2 ng mus m1/ml]. Sociodemographic data, personal history of allergies and cleaning habits, as well as work-related characteristics (LAW only) were assessed by questionnaire. Latent factors were assessed via factor analysis. Tobit models were fitted to analyse the latent factors’ contribution to MA spreading. RESULTS: MA concentration on the seating was significantly higher in home environments of LAW (median = 1.28 ng mus m1/m(2)) than in the comparison group (median < DL, p = 0.019). The highest workplace MA concentration was found on the floor of the scullery (median = 140,000.00 ng mus m1/m(2)), followed by hair-covering caps (median = 76.02 ng mus m1/m(2)). Cage and mouse facility cleaning tasks and infrequent changing of bed linen at home were statistically significantly associated with higher MA concentrations at home. CONCLUSIONS: Spreading of MA from LAW’s workplace to their home environment takes place, especially among LAWs involved in cleaning tasks. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00420-020-01603-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-8068679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-80686792021-05-05 From workplace to home environment: spreading of mouse allergens by laboratory animal workers Kube, Hannah Herrera, Ronald Dietrich-Gümperlein, Gisela Schierl, Rudolf Nowak, Dennis Radon, Katja Wengenroth, Laura Gerlich, Jessica Int Arch Occup Environ Health Original Article PURPOSE: Laboratory animal workers (LAW) working with laboratory mice are exposed to mouse allergens (MA). If MA are spread to home environments, this might increase the risk for allergies in LAW and their families. This study aimed to assess 1. whether spreading of MA from workplace to home environment takes place; 2. which factors increase spreading of MA. METHODS: In a cross-sectional study, dust samples were taken on the mattress and seating in homes of LAW (n = 105) and an unexposed comparison group (n = 13). From 89 LAW, additional dust samples were taken from their workplaces. Samples were analysed using Mus m1 ELISA kits [detection limit (DL) 0.2 ng mus m1/ml]. Sociodemographic data, personal history of allergies and cleaning habits, as well as work-related characteristics (LAW only) were assessed by questionnaire. Latent factors were assessed via factor analysis. Tobit models were fitted to analyse the latent factors’ contribution to MA spreading. RESULTS: MA concentration on the seating was significantly higher in home environments of LAW (median = 1.28 ng mus m1/m(2)) than in the comparison group (median < DL, p = 0.019). The highest workplace MA concentration was found on the floor of the scullery (median = 140,000.00 ng mus m1/m(2)), followed by hair-covering caps (median = 76.02 ng mus m1/m(2)). Cage and mouse facility cleaning tasks and infrequent changing of bed linen at home were statistically significantly associated with higher MA concentrations at home. CONCLUSIONS: Spreading of MA from LAW’s workplace to their home environment takes place, especially among LAWs involved in cleaning tasks. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00420-020-01603-9) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-11-21 2021 /pmc/articles/PMC8068679/ /pubmed/33219477 http://dx.doi.org/10.1007/s00420-020-01603-9 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Kube, Hannah Herrera, Ronald Dietrich-Gümperlein, Gisela Schierl, Rudolf Nowak, Dennis Radon, Katja Wengenroth, Laura Gerlich, Jessica From workplace to home environment: spreading of mouse allergens by laboratory animal workers |
title | From workplace to home environment: spreading of mouse allergens by laboratory animal workers |
title_full | From workplace to home environment: spreading of mouse allergens by laboratory animal workers |
title_fullStr | From workplace to home environment: spreading of mouse allergens by laboratory animal workers |
title_full_unstemmed | From workplace to home environment: spreading of mouse allergens by laboratory animal workers |
title_short | From workplace to home environment: spreading of mouse allergens by laboratory animal workers |
title_sort | from workplace to home environment: spreading of mouse allergens by laboratory animal workers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068679/ https://www.ncbi.nlm.nih.gov/pubmed/33219477 http://dx.doi.org/10.1007/s00420-020-01603-9 |
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