Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia

Under conditions of lymphopenia, T lymphocytes proliferate and acquire a surface activation phenotype, which in many respects is similar to the phenotype of true memory T cells. We investigated the phenotypic features of the CD8+ T-cell population formed from donor lymphocytes after adoptive transfe...

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Autores principales: Silaeva, Yu. Yu., Kalinina, A. A., Khromykh, L. M., Deykin, A. V., Kazansky, D. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068684/
https://www.ncbi.nlm.nih.gov/pubmed/33666806
http://dx.doi.org/10.1134/S1607672921020137
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author Silaeva, Yu. Yu.
Kalinina, A. A.
Khromykh, L. M.
Deykin, A. V.
Kazansky, D. B.
author_facet Silaeva, Yu. Yu.
Kalinina, A. A.
Khromykh, L. M.
Deykin, A. V.
Kazansky, D. B.
author_sort Silaeva, Yu. Yu.
collection PubMed
description Under conditions of lymphopenia, T lymphocytes proliferate and acquire a surface activation phenotype, which in many respects is similar to the phenotype of true memory T cells. We investigated the phenotypic features of the CD8+ T-cell population formed from donor lymphocytes after adoptive transfer of syngeneic splenocytes to sublethally irradiated mice. This population expresses markers CD44, CD122, CD5, CD49d and the chemokine receptor CXCR3. Thus, for the first time, the phenomenon of the formation of a population of T cells with signs of suppressive CD8+ T lymphocytes and true memory cells was demonstrated.
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spelling pubmed-80686842021-05-05 Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia Silaeva, Yu. Yu. Kalinina, A. A. Khromykh, L. M. Deykin, A. V. Kazansky, D. B. Dokl Biochem Biophys Biochemistry, Biophysics, and Molecular Biology Under conditions of lymphopenia, T lymphocytes proliferate and acquire a surface activation phenotype, which in many respects is similar to the phenotype of true memory T cells. We investigated the phenotypic features of the CD8+ T-cell population formed from donor lymphocytes after adoptive transfer of syngeneic splenocytes to sublethally irradiated mice. This population expresses markers CD44, CD122, CD5, CD49d and the chemokine receptor CXCR3. Thus, for the first time, the phenomenon of the formation of a population of T cells with signs of suppressive CD8+ T lymphocytes and true memory cells was demonstrated. Pleiades Publishing 2021-03-05 2021 /pmc/articles/PMC8068684/ /pubmed/33666806 http://dx.doi.org/10.1134/S1607672921020137 Text en © The Author(s) 2021, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2021, Vol. 497, pp. 71–74. © The Author(s), 2021. This article is an open access publication.Russian Text © The Author(s), 2021, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2021, Vol. 497, pp. 165–168. https://creativecommons.org/licenses/by/4.0/Open Access.This article is distributed under the terms of the Creative Commons Attribution 4.0 International Public License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Biochemistry, Biophysics, and Molecular Biology
Silaeva, Yu. Yu.
Kalinina, A. A.
Khromykh, L. M.
Deykin, A. V.
Kazansky, D. B.
Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia
title Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia
title_full Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia
title_fullStr Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia
title_full_unstemmed Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia
title_short Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia
title_sort formation of a unique population of cd8+ t lymphocytes after adoptive transfer of syngeneic splenocytes to mice with lymphopenia
topic Biochemistry, Biophysics, and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068684/
https://www.ncbi.nlm.nih.gov/pubmed/33666806
http://dx.doi.org/10.1134/S1607672921020137
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