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Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study

Sodium effects on proteinuria are debated. This observational, cross-sectional, population-based study investigated relationships to proteinuria and albuminuria of sodium intake assessed as urinary sodium/creatinine ratio (NaCR). In 482 men and 454 women aged 35–94 years from the Moli-sani study, da...

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Autores principales: Cirillo, Massimo, Cavallo, Pierpaolo, Zulli, Enrico, Villa, Rachele, Veneziano, Rosangela, Costanzo, Simona, Magnacca, Sara, Di Castelnuovo, Augusto, Iacoviello, Licia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068813/
https://www.ncbi.nlm.nih.gov/pubmed/33920400
http://dx.doi.org/10.3390/nu13041255
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author Cirillo, Massimo
Cavallo, Pierpaolo
Zulli, Enrico
Villa, Rachele
Veneziano, Rosangela
Costanzo, Simona
Magnacca, Sara
Di Castelnuovo, Augusto
Iacoviello, Licia
author_facet Cirillo, Massimo
Cavallo, Pierpaolo
Zulli, Enrico
Villa, Rachele
Veneziano, Rosangela
Costanzo, Simona
Magnacca, Sara
Di Castelnuovo, Augusto
Iacoviello, Licia
author_sort Cirillo, Massimo
collection PubMed
description Sodium effects on proteinuria are debated. This observational, cross-sectional, population-based study investigated relationships to proteinuria and albuminuria of sodium intake assessed as urinary sodium/creatinine ratio (NaCR). In 482 men and 454 women aged 35–94 years from the Moli-sani study, data were collected for the following: urinary NaCR (independent variable); urinary total proteins/creatinine ratio (PCR, mg/g), urinary albumin/creatinine ratio (ACR, mg/g), and urinary non-albumin-proteins/creatinine ratio (calculated as PCR minus ACR) (dependent variables). High values were defined as PCR ≥ 150 mg/g, ACR ≥ 30 mg/g, and urinary non-albumin-proteins/creatinine ratio ≥ 120 mg/g. Urinary variables were measured in first-void morning urine. Skewed variables were log-transformed in analyses. The covariates list included sex, age, energy intake, body mass index, waist/hip ratio, estimated urinary creatinine excretion, smoking, systolic pressure, diastolic pressure, diabetes, history of cardiovascular disease, reported treatment with antihypertensive drug, inhibitor or blocker of the renin-angiotensin system, diuretic, and log-transformed data of total physical activity, leisure physical activity, alcohol intake, and urinary ratios of urea nitrogen, potassium, and phosphorus to creatinine. In multivariable linear regression, standardized beta coefficients of urinary NaCR were positive with PCR (women and men = 0.280 and 0.242, 95% confidence interval = 0.17/0.39 and 0.13/0.35, p < 0.001), ACR (0.310 and 0.265, 0.20/0.42 and 0.16/0.38, p < 0.001), and urinary non-albumin-proteins/creatinine ratio (0.247 and 0.209, 0.14/0.36 and 0.09/0.33, p < 0.001). In multivariable logistic regression, higher quintile of urinary NaCR associated with odds ratio of 1.81 for high PCR (1.55/2.12, p < 0.001), 0.51 of 1.62 for high ACR (1.35/1.95, p < 0.001), and of 1.84 for high urinary non-albumin proteins/creatinine ratio (1.58/2.16, p < 0.001). Findings were consistent in subgroups. Data indicate independent positive associations of an index of sodium intake with proteinuria and albuminuria in the population.
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spelling pubmed-80688132021-04-26 Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study Cirillo, Massimo Cavallo, Pierpaolo Zulli, Enrico Villa, Rachele Veneziano, Rosangela Costanzo, Simona Magnacca, Sara Di Castelnuovo, Augusto Iacoviello, Licia Nutrients Article Sodium effects on proteinuria are debated. This observational, cross-sectional, population-based study investigated relationships to proteinuria and albuminuria of sodium intake assessed as urinary sodium/creatinine ratio (NaCR). In 482 men and 454 women aged 35–94 years from the Moli-sani study, data were collected for the following: urinary NaCR (independent variable); urinary total proteins/creatinine ratio (PCR, mg/g), urinary albumin/creatinine ratio (ACR, mg/g), and urinary non-albumin-proteins/creatinine ratio (calculated as PCR minus ACR) (dependent variables). High values were defined as PCR ≥ 150 mg/g, ACR ≥ 30 mg/g, and urinary non-albumin-proteins/creatinine ratio ≥ 120 mg/g. Urinary variables were measured in first-void morning urine. Skewed variables were log-transformed in analyses. The covariates list included sex, age, energy intake, body mass index, waist/hip ratio, estimated urinary creatinine excretion, smoking, systolic pressure, diastolic pressure, diabetes, history of cardiovascular disease, reported treatment with antihypertensive drug, inhibitor or blocker of the renin-angiotensin system, diuretic, and log-transformed data of total physical activity, leisure physical activity, alcohol intake, and urinary ratios of urea nitrogen, potassium, and phosphorus to creatinine. In multivariable linear regression, standardized beta coefficients of urinary NaCR were positive with PCR (women and men = 0.280 and 0.242, 95% confidence interval = 0.17/0.39 and 0.13/0.35, p < 0.001), ACR (0.310 and 0.265, 0.20/0.42 and 0.16/0.38, p < 0.001), and urinary non-albumin-proteins/creatinine ratio (0.247 and 0.209, 0.14/0.36 and 0.09/0.33, p < 0.001). In multivariable logistic regression, higher quintile of urinary NaCR associated with odds ratio of 1.81 for high PCR (1.55/2.12, p < 0.001), 0.51 of 1.62 for high ACR (1.35/1.95, p < 0.001), and of 1.84 for high urinary non-albumin proteins/creatinine ratio (1.58/2.16, p < 0.001). Findings were consistent in subgroups. Data indicate independent positive associations of an index of sodium intake with proteinuria and albuminuria in the population. MDPI 2021-04-11 /pmc/articles/PMC8068813/ /pubmed/33920400 http://dx.doi.org/10.3390/nu13041255 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cirillo, Massimo
Cavallo, Pierpaolo
Zulli, Enrico
Villa, Rachele
Veneziano, Rosangela
Costanzo, Simona
Magnacca, Sara
Di Castelnuovo, Augusto
Iacoviello, Licia
Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study
title Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study
title_full Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study
title_fullStr Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study
title_full_unstemmed Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study
title_short Sodium Intake and Proteinuria/Albuminuria in the Population—Observational, Cross-Sectional Study
title_sort sodium intake and proteinuria/albuminuria in the population—observational, cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068813/
https://www.ncbi.nlm.nih.gov/pubmed/33920400
http://dx.doi.org/10.3390/nu13041255
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