Cargando…
Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors
Identification of Na(+)/taurocholate co-transporting polypeptide (NTCP) as high-affinity hepatic entry receptor for the Hepatitis B and D viruses (HBV/HDV) opened the field for target-based development of cell-entry inhibitors. However, most of the HBV/HDV entry inhibitors identified so far also int...
Autores principales: | Kirstgen, Michael, Lowjaga, Kira Alessandra Alicia Theresa, Müller, Simon Franz, Goldmann, Nora, Lehmann, Felix, Glebe, Dieter, Baringhaus, Karl-Heinz, Geyer, Joachim |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068820/ https://www.ncbi.nlm.nih.gov/pubmed/33921515 http://dx.doi.org/10.3390/v13040666 |
Ejemplares similares
-
Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening
por: Kirstgen, Michael, et al.
Publicado: (2021) -
Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids
por: Kirstgen, Michael, et al.
Publicado: (2020) -
IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection
por: Palatini, Massimo, et al.
Publicado: (2022) -
Mutational Analysis of the GXXXG/A Motifs in the Human Na(+)/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function
por: Palatini, Massimo, et al.
Publicado: (2021) -
Tyrosine 146 of the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)