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Natural Cyclopeptides as Anticancer Agents in the Last 20 Years
Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino acids. A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. Compared to linear peptides, cyclope...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068844/ https://www.ncbi.nlm.nih.gov/pubmed/33921480 http://dx.doi.org/10.3390/ijms22083973 |
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author | Zhang, Jia-Nan Xia, Yi-Xuan Zhang, Hong-Jie |
author_facet | Zhang, Jia-Nan Xia, Yi-Xuan Zhang, Hong-Jie |
author_sort | Zhang, Jia-Nan |
collection | PubMed |
description | Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino acids. A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. Compared to linear peptides, cyclopeptides have absolute advantages of structural rigidity, biochemical stability, binding affinity as well as membrane permeability, which contribute greatly to their anticancer potency. Therefore, the discovery and development of natural cyclopeptides as anticancer agents remains attractive to academic researchers and pharmaceutical companies. Herein, we provide an overview of anticancer cyclopeptides that were discovered in the past 20 years. The present review mainly focuses on the anticancer efficacies, mechanisms of action and chemical structures of cyclopeptides with natural origins. Additionally, studies of the structure–activity relationship, total synthetic strategies as well as bioactivities of natural cyclopeptides are also included in this article. In conclusion, due to their characteristic structural features, natural cyclopeptides have great potential to be developed as anticancer agents. Indeed, they can also serve as excellent scaffolds for the synthesis of novel derivatives for combating cancerous pathologies. |
format | Online Article Text |
id | pubmed-8068844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80688442021-04-26 Natural Cyclopeptides as Anticancer Agents in the Last 20 Years Zhang, Jia-Nan Xia, Yi-Xuan Zhang, Hong-Jie Int J Mol Sci Review Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino acids. A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. Compared to linear peptides, cyclopeptides have absolute advantages of structural rigidity, biochemical stability, binding affinity as well as membrane permeability, which contribute greatly to their anticancer potency. Therefore, the discovery and development of natural cyclopeptides as anticancer agents remains attractive to academic researchers and pharmaceutical companies. Herein, we provide an overview of anticancer cyclopeptides that were discovered in the past 20 years. The present review mainly focuses on the anticancer efficacies, mechanisms of action and chemical structures of cyclopeptides with natural origins. Additionally, studies of the structure–activity relationship, total synthetic strategies as well as bioactivities of natural cyclopeptides are also included in this article. In conclusion, due to their characteristic structural features, natural cyclopeptides have great potential to be developed as anticancer agents. Indeed, they can also serve as excellent scaffolds for the synthesis of novel derivatives for combating cancerous pathologies. MDPI 2021-04-12 /pmc/articles/PMC8068844/ /pubmed/33921480 http://dx.doi.org/10.3390/ijms22083973 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Jia-Nan Xia, Yi-Xuan Zhang, Hong-Jie Natural Cyclopeptides as Anticancer Agents in the Last 20 Years |
title | Natural Cyclopeptides as Anticancer Agents in the Last 20 Years |
title_full | Natural Cyclopeptides as Anticancer Agents in the Last 20 Years |
title_fullStr | Natural Cyclopeptides as Anticancer Agents in the Last 20 Years |
title_full_unstemmed | Natural Cyclopeptides as Anticancer Agents in the Last 20 Years |
title_short | Natural Cyclopeptides as Anticancer Agents in the Last 20 Years |
title_sort | natural cyclopeptides as anticancer agents in the last 20 years |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068844/ https://www.ncbi.nlm.nih.gov/pubmed/33921480 http://dx.doi.org/10.3390/ijms22083973 |
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