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Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α

Hypoxia inducible factor (HIF)-1α has been implicated in the pathogenesis of rheumatoid arthritis (RA). HIF-1α, which is expressed in hypoxia, is reversely suppressed in sustained hypoxia. Here, we investigated the inhibitory effect of hypoxia on arthritis by controlling HIF-1α. Rheumatoid fibroblas...

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Detalles Bibliográficos
Autores principales:	Kaihara, Kenta, Nakagawa, Shuji, Arai, Yuji, Inoue, Hiroaki, Tsuchida, Shinji, Fujii, Yuta, Kamada, Yoichiro, Kishida, Tsunao, Mazda, Osam, Takahashi, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068944/ https://www.ncbi.nlm.nih.gov/pubmed/33918929 http://dx.doi.org/10.3390/ijms22083898

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